Pinoresinol Diglucoside Alleviates oxLDL-Induced Dysfunction in Human Umbilical Vein Endothelial Cells

Figure 6

The oxLDL promoted activation of p38MAPK/NF-κB signaling is inhibited by pinoresinol diglucoside. (a) HUVECs were treated with or without 1 μmol/L of PD for 60 min before being treated with 40 mg/mL of oxLDL for 45 min. The levels of p-p38MAPK, p38MAPK, p-NF-κB p65, and NF-κB p65 were analyzed by western blot. The ratio of p-p38MAPK/p38MAPK (b) and p-NF-κB p65/NF-κB p65 (c) was shown. Experiments were performed 3 independent times with 3 replications. compared to control cells; compared to oxLDL-treated cells.

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