Reproductive Toxicity of Zishen Yutai Pill in Rats: The Fertility and Early Embryonic Development Study (Segment I)

Table 4

Changes in weight and food intake of female rats during the premating and gestation period.

Terms	Days	Vehicle control group	Positive control group	Zishen Yutai Pill-treated groups
				Low dose-treated group	Moderate dose-treated group	High dose-treated group
Weight (g)
Premating period	D1	210.9 ± 10.5	213.7 ± 11.2	214.1 ± 11.5	212.5 ± 11.1	214.3 ± 11.6
	D4	221.8 ± 12.7	212.8 ± 9.6	216.6 ± 14.4	217.3 ± 12.2	218.2 ± 12.4
	D8	230.8 ± 17.4	217.7 ± 12.8	223.6 ± 16.2	224.0 ± 13.7	225.1 ± 16.9
	D11	231.3 ± 15.7	222.1 ± 11.8	226.6 ± 13.2	225.3 ± 11.6	227.3 ± 13.8
Gestation period	GD0	231.4 ± 14.3	225.7 ± 11.2	227.8 ± 13.7	227.2 ± 15.1	232.2 ± 16.5
	GD3	247.7 ± 16.7	243.9 ± 10.9	244.1 ± 15.4	244.3 ± 14.8	247.4 ± 13.8
	GD7	262.2 ± 16.1	259.5 ± 11.2	258.8 ± 14.6	256.8 ± 16.2	259.0 ± 14.4
	GD10	274.4 ± 15.9	270.5 ± 12.2	269.8 ± 14.1	267.7 ± 17.5	272.4 ± 16.2
	GD14	291.5 ± 18.8	280.2 ± 21.1	289.5 ± 14.5	287.3 ± 17.7	292.2 ± 17.6
Extra-uterine weight gain		48.7 ± 11.3	43.5 ± 16.1	50.5 ± 5.7	49.5 ± 7.1	48.9 ± 9.0
Food intake (g/d)
Premating period	D1	15.4 ± 1.4	8.2 ± 1.8	15.6 ± 0.5	15.1 ± 2.4	14.5 ± 1.5
	D8	17.0 ± 1.8	18.7 ± 2.4	18.0 ± 1.9	18.3 ± 0.6	20.4 ± 1.7
Gestation period	GD0	17.0 ± 4.2	18.0 ± 4.2	16.0 ± 2.7	16.1 ± 3.2	16.5 ± 2.5
	GD6	21.8 ± 2.6	23.6 ± 1.9	22.3 ± 2.0	21.1 ± 3.3	21.0 ± 2.8
	GD13	22.3 ± 2.2	24.1 ± 4.0	23.2 ± 2.3	23.1 ± 2.8	23.0 ± 2.5

⁢ and compared with the vehicle control group.
Extra-uterine weight gain: (weight on GD₁₄) − (weight on GD₀) − (total weight of the gravid uterus).