Evaluation of the In Vivo Therapeutic Effects of Radix Paeoniae Rubra Ethanol Extract with the Hypoglycemic Activities Measured from Multiple Cell-Based Assays

Figure 4

Evaluation acute and long-term hypoglycemic effects of PRExt on db/db T2D mice. (a) Fasting blood glucose of db/db mice were intraperitoneal injected with PRExt at indicated dosages. Acute blood glucose changes are recorded at 0, 15 min, 30 min, 1 h, 2 h, 4 h, 6 h, 8 h, 10 h, and 12 h, respectively. Data are presented as the mean ± SEM (/group). and when compared with data of vehicle group at 12 h. (b) The long-term state blood sugar of C57J mice and db/db control mice in the presence or absence of oral administration of PRExt (200 mg/kg/day). Data are presented as the mean ± SEM (–10/group). when compared with untreated db/db mice.

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