Evaluation of the In Vivo Therapeutic Effects of Radix Paeoniae Rubra Ethanol Extract with the Hypoglycemic Activities Measured from Multiple Cell-Based Assays

Figure 5

Therapeutic effects of PRExt in treating dysglycemia in db/db T2D mice. The results of (a) HOMA-IR, (b) HOMA-B%, and (c) glucose tolerance of C57J mice and db/db control mice in the presence or absence of PRExt treatment. Data are presented as the mean ± SEM (–10/group). , , and when compared with untreated db/db mice. (d) Representative results of 2-[¹⁸F]-fluorodeoxyglucose (FDG) biodistribution measured by micro-PET scanning. (e) Quantitative results of upper and lower limbs after FDG uptake. Data are presented as the mean ± SEM (/group). when compared with FDG uptake activity between upper and lower limbs in the same mice. when compared with FDG uptake activity of the corresponding limb region in untreated db/db mice.

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