Key Molecular Mechanisms of Chaiqinchengqi Decoction in Alleviating the Pulmonary Albumin Leakage Caused by Endotoxemia in Severe Acute Pancreatitis Rats
Table 6
The proinflammatory cytokines release, TEER, and paracellular leakage in HUVECs.
Indexes
Normal
LPS (1 mg/L)
CQCQD (1 mg/L)
Inhibition agents
siRNA (c-F-os)
PP1 (10 M)
LY294002 (30 M)
TNF- (ng/mL)
1.85 ± 0.35
12.46 ± 0.41▲
9.32 ± 0.58△
5.85 ± 0.28☆
6.78 ± 0.31
5.18 ± 0.33
IL-6 (ρg/mL)
32.19 ± 7.55
318.45 ± 9.47▲
194.33 ± 8.61△
112.18 ± 9.98☆
121.23 ± 10.45
98.56 ± 10.10
IL-1 (ρg/mL)
10.75 ± 1.03
112.42 ± 4.55▲
58.16 ± 3.93△
45.78 ± 3.03☆
48.24 ± 3.56
42.66 ± 3.75
TEER (Ω⋅cm2)
25.12 ± 1.66
18.61 ± 0.98▲
21.23 ± 1.12△
23.89 ± 1.03☆
22.64 ± 1.23
23.13 ± 1.01
Dextran flux (cm/s)
0.22 ± 0.12
0.48 ± 0.29▲
0.33 ± 0.22△
0.31 ± 0.18☆
0.28 ± 0.16
0.26 ± 0.14
versus Normal, versus LPS, versus LPS, versus LPS, and versus LPS.
