Table of Contents Author Guidelines Submit a Manuscript
Evidence-Based Complementary and Alternative Medicine
Volume 2016 (2016), Article ID 3281968, 19 pages
http://dx.doi.org/10.1155/2016/3281968
Review Article

Chinese Herbal Medicine as Adjunctive Therapy to Chemotherapy for Breast Cancer: A Systematic Review and Meta-Analysis

1Department of Oncology, Beijing Hospital of Traditional Chinese Medicine, Capital Medical University, Beijing 100010, China
2Beijing University of Chinese Medicine, Beijing 100029, China
3Department of Oncology, Third Affiliated Hospital of Henan College of Traditional Chinese Medicine, Zhengzhou 450000, China
4Department of Medical Biochemistry and Microbiology, Uppsala University, 75123 Uppsala, Sweden

Received 27 October 2015; Revised 6 February 2016; Accepted 1 March 2016

Academic Editor: Kamal D. Moudgil

Copyright © 2016 Xu Sun et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. L. A. Torre, F. Bray, R. L. Siegel, J. Ferlay, J. Lortet-Tieulent, and A. Jemal, “Global cancer statistics, 2012,” CA Cancer Journal for Clinicians, vol. 65, no. 2, pp. 87–108, 2015. View at Publisher · View at Google Scholar · View at Scopus
  2. L. You, R. An, K. Liang, and X. Wang, “Anti-breast cancer agents from Chinese herbal medicines,” Mini-Reviews in Medicinal Chemistry, vol. 13, no. 1, pp. 101–105, 2013. View at Publisher · View at Google Scholar · View at Scopus
  3. L. Del Mastro, A. Fabi, M. Mansutti et al., “Randomised phase 3 open-label trial of first-line treatment with gemcitabine in association with docetaxel or paclitaxel in women with metastatic breast cancer: a comparison of different schedules and treatments,” BMC Cancer, vol. 13, article 164, 2013. View at Publisher · View at Google Scholar · View at Scopus
  4. D. Amadori, O. Nanni, M. Marangolo et al., “Disease-free survival advantage of adjuvant cyclophosphamide, methotrexate, and fluorouracil in patients with node-negative, rapidly proliferating breast cancer: a randomized multicenter study,” Journal of Clinical Oncology, vol. 18, no. 17, pp. 3125–3134, 2000. View at Google Scholar · View at Scopus
  5. P. Rastogi, S. J. Anderson, H. D. Bear et al., “Preoperative chemotherapy: updates of National Surgical Adjuvant Breast and Bowel Project Protocols B-18 and B-27,” Journal of Clinical Oncology, vol. 26, no. 5, pp. 778–785, 2008. View at Publisher · View at Google Scholar · View at Scopus
  6. K. Boér, I. Láng, E. Juhos, T. Pintér, and J. Szántó, “Adjuvant therapy of breast cancer with docetaxel-containing combination (TAC),” Pathology & Oncology Research, vol. 9, no. 3, pp. 166–169, 2003. View at Google Scholar
  7. P. Harris and R. Rees, “The prevalence of complementary and alternative medicine use among the general population: a systematic review of the literature,” Complementary Therapies in Medicine, vol. 8, no. 2, pp. 88–96, 2000. View at Publisher · View at Google Scholar · View at Scopus
  8. E. Ernst, “Prevalence of use of complementary/alternative medicine: a systematic review,” Bulletin of the World Health Organization, vol. 78, no. 2, pp. 252–257, 2000. View at Google Scholar · View at Scopus
  9. H. A. Tindle, R. B. Davis, R. S. Phillips, and D. M. Eisenberg, “Trends in use of complementary and alternative medicine by us adults: 1997–2002,” Alternative Therapies in Health and Medicine, vol. 11, no. 1, pp. 42–49, 2005. View at Google Scholar · View at Scopus
  10. C. C. L. Xue, A. L. Zhang, V. Lin, C. Da Costa, and D. F. Story, “Complementary and alternative medicine use in Australia: a national population-based survey,” Journal of Alternative and Complementary Medicine, vol. 13, no. 6, pp. 643–650, 2007. View at Publisher · View at Google Scholar · View at Scopus
  11. E. Ernst and A. White, “The BBC survey of complementary medicine use in the UK,” Complementary Therapies in Medicine, vol. 8, no. 1, pp. 32–36, 2000. View at Publisher · View at Google Scholar · View at Scopus
  12. W. J. Millar, “Use of alternative health care practitioners by Canadians,” Canadian Journal of Public Health, vol. 88, no. 3, pp. 154–158, 1997. View at Google Scholar · View at Scopus
  13. U. Wolf, S. Maxion-Bergemann, G. Bornhöft, P. F. Matthiessen, and M. Wolf, “Use of complementary medicine in Switzerland,” Forschende Komplementarmedizin, vol. 13, no. 2, pp. 4–6, 2006. View at Publisher · View at Google Scholar · View at Scopus
  14. B. Hanssen, S. Grimsgaard, L. Launsø, V. Fønnebø, T. Falkenberg, and N. K. Rasmussen, “Use of complementary and alternative medicine in the Scandinavian countries,” Scandinavian Journal of Primary Health Care, vol. 23, no. 1, pp. 57–62, 2005. View at Publisher · View at Google Scholar · View at Scopus
  15. K. Thomas and P. Coleman, “Use of complementary or alternative medicine in a general population in Great Britain. Results from the National Omnibus survey,” Journal of Public Health, vol. 26, no. 2, pp. 152–157, 2004. View at Publisher · View at Google Scholar · View at Scopus
  16. B. Wang, The Yellow Emperor's Classic of Internal Medicine—Simple Questions, People's Health Publishing House, Beijing, China, 1979.
  17. D. Tian, Spiritual Axis, People's Health Publishing House, Beijing, China, 2005.
  18. I. Cohen, M. Tagliaferri, and D. Tripathy, “Traditional Chinese medicine in the treatment of breast cancer,” Seminars in Oncology, vol. 29, no. 6, pp. 563–574, 2002. View at Publisher · View at Google Scholar · View at Scopus
  19. D. Moher, A. Liberati, J. Tetzlaff, and D. G. Altman, “Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement,” Open Medicine, vol. 3, no. 3, pp. e123–e130, 2009. View at Publisher · View at Google Scholar · View at Scopus
  20. A. R. Jadad, R. A. Moore, D. Carroll et al., “Assessing the quality of reports of randomized clinical trials: is blinding necessary?” Controlled Clinical Trials, vol. 17, no. 1, pp. 1–12, 1996. View at Publisher · View at Google Scholar · View at Scopus
  21. J. P. T. Higgins, D. G. Altman, P. C. Gøtzsche et al., “The Cochrane Collaboration's tool for assessing risk of bias in randomised trials,” The British Medical Journal, vol. 343, no. 7829, Article ID d5928, 2011. View at Publisher · View at Google Scholar · View at Scopus
  22. X. G. Dang and L. Wang, “Evaluation of efficacy on breast cancer treated by Aidi injection plus CTF program of neoadjuvant chemotherapy and the impacts on serum sFas,” World Journal of Integrated Traditional and Western Medicine, vol. 5, no. 1, pp. 54–56, 2010. View at Google Scholar
  23. D. L. Barton, K. Burger, P. J. Novotny et al., “The use of Ginkgo biloba for the prevention of chemotherapy-related cognitive dysfunction in women receiving adjuvant treatment for breast cancer, N00C9,” Supportive Care in Cancer, vol. 21, no. 4, pp. 1185–1192, 2013. View at Publisher · View at Google Scholar · View at Scopus
  24. X. D. Fang, “Clinical observation on Jianpi Yiqi formula combined with chemotherapy in the treatment of 30 cases with advanced breast cancer,” Journal of Traditional Chinese Medicine, vol. 50, supplement 1, pp. 174–176.
  25. L. Fu and X. G. Kou, “Clinical observation on Aidi injection combined with chemotherapy in the treatment of 44 cases with breast cancer,” Journal of Practical Traditional Chinese Medicine, vol. 23, no. 8, p. 517.
  26. R. Hong, Y. Q. Wu, and Y. Wu, “Effects of Xihuangwan in assistanr treatment of patients with advanced breast cancer,” Zhong Guo Zhong Yao Za Zhi, vol. 39, no. 6, pp. 1120–1123, 2014. View at Google Scholar
  27. Z. F. Huang, J. S. Wei, Z. Y. Shi, and K. Zhong, “Study of Bazhen decoction and chemotherapy on mammary cancer in metaphase or later period,” Xian Dai Zhong Xi Yi Jie He Za Zhi, vol. 12, no. 11, pp. 1123–1126, 2003. View at Google Scholar
  28. Z. F. Huang, J. B. Liu, Q. S. Chen, H. Z. Li, Z. J. Zhang, and C. J. Huang, “The influence of Jianpi Xiaoji Tang combined with chemotherapy on life quality and immunologic function in late stage of mammary cancer,” Journal of New Chinese Medicine, vol. 39, no. 5, pp. 88–89.
  29. Z. F. Huang, J. S. Wei, H. Z. Li, Z. Q. Tan, Z. J. Zhang, and C. Chen, “Effect of Shenqi Fuzheng injection combined with chemotherapy on thirty patients with advanced breast cancer,” Chinese Journal of Integrated Traditional and Western Medicine, vol. 28, no. 2, pp. 152–154, 2008. View at Google Scholar
  30. C. J. Huang, J. B. Liu, and T. H. Liao, “Effect of Astragalus injection combined chemotherapy on life quality and immune function in advanced breast cancer,” Nei Mongol Journal of Traditional Chinese Medicine, vol. 32, no. 32, pp. 66–67.
  31. X. Q. Li, Y. Wang, S. T. Zhao, X. H. Ni, and S. Q. Ma, “Clinical observation on no. 1 decoction of Rukang affecting breast cancer matastasis of 61 cases,” Chinese Journal of Traditional Medical Science and Technology, vol. 10, no. 5, pp. 305–306.
  32. X. Q. Li and S. B. Gong, “Effect of Aidi injection combined with CEF regimn chemotherapy in the treatment of breast cancer,” Pharmacology and Clinics of Chinese Materia Medica, vol. 3, no. 22, pp. 176–177.
  33. X. A. Lu, “Effect of Astragalus Injection on the Quality of breast cancer patients,” Zhong Guo Zhong Yi Yao Xian Dai Yuan Cheng Jiao Yu, vol. 8, no. 11, pp. 36–37.
  34. Y. Lv, L. Z. Huang, D. Mao, X. J. Dai, J. Yang, and S. Q. Zhang, “Clinical research on treatment of advanced breast cancer based on Yiqi Huoxue method combined with chemotherapy,” Acta Chinese Medicine and Pharmacology, vol. 42, no. 3, pp. 93–96.
  35. X. L. Ni, “Clinical study of gaolishen injection combined with chemotherapy for the advanced breast cancer,” China Practical Medical, vol. 1, no. 4, pp. 64–65.
  36. D. Pérol, J. Provençal, A.-C. Hardy-Bessard et al., “Can treatment with Cocculine improve the control of chemotherapy-induced emesis in early breast cancer patients? A randomized, multi-centered, double-blind, placebo-controlled Phase III trial,” BMC Cancer, vol. 12, article 603, 2012. View at Publisher · View at Google Scholar · View at Scopus
  37. M. H. Qi, Clinical Research of Breast Cancer Treatments by Yiqi Yangxue Shugan Decotion Assisting TE Chemotherapy, The First Clinical Medical College, Nanjing University of Chinese Medicine, 2010.
  38. L. Qin, “Effect of Fuzheng Yiqi Jiedu decoction in the treatment of 39 breast cancer cases after surgery,” Traditional Chinese Medicine Rearch, vol. 26, no. 7, pp. 19–21.
  39. V. F. Semiglazov, V. V. Stepula, A. Dudov, J. Schnitker, and U. Mengs, “Quality of life is improved in breast cancer patients by standardised mistletoe extract PS76A2 during chemotherapy and follow-up: a randomised, placebo-controlled, double-blind, multicentre clinical trial,” Anticancer Research, vol. 26, no. 2, pp. 1519–1529, 2006. View at Google Scholar · View at Scopus
  40. T. Shen, “Clinical observation of Aiyishu injection combined with chemotherapy in advanced stage breast cancer,” China Medicine Guides, vol. 4, no. 26, pp. 44–45.
  41. W. H. Sun, M. Y. Luo, and J. Yu, “Preventive effect of Zanfan pill on the myelosupression of breast cancer patients receiving chemotherapy,” Strait Pharmaceutical Journal, vol. 22, no. 5, pp. 100–102.
  42. Y. H. Wang, Effect on Quality of Life about Paients with Breast Cancer Received Neoadjuvant Chemotherapy and Taohong Siwu Tang, Guangzhou University of Chinese Medicine, 2007.
  43. L. F. Wang, Impact on QOL of Patients with Advanced Breast Cancer Treated by YiQiJianPi and HuaYuJieDu Method Combined with TE Regiment Chemotherapy, The First Clinical Medical College, Nanjing University of Chinese Medicine, 2010.
  44. H. Y. Wen, Y. L. Ma, and C. X. Wang, “Effect on QOL and immunity of patients with advanced breast cancer treated by fuzheng xiaoyan decoction combined with chemotherapy,” Jiang Su Zhong Yi Yao, vol. 42, no. 8, pp. 23–24.
  45. L. G. Xiong, “Study on the effect of Fuzheng Xiaoji recipe combined with chemotherapy on the life quality and serum tumor markers of late breast cancer patients,” Yunnan Journal of Traditional Chinese Medicine and Materia Medica, vol. 33, no. 4, pp. 14–15, 2012. View at Google Scholar
  46. L. Yang, “Clinical study of Aidi injection combined with chemotherapy on advanced breast cancer,” Chinese Journal of Integrated Traditional and Western Medicine, vol. 24, no. 8, pp. 755–756, 2004. View at Google Scholar
  47. G. W. Yang, Y. M. Xu, Q. Fu et al., “Clinical observation on Gubne Yiliu II combined with chemotherapy in the treatment of 28 cases of advanced breast cancer,” Journal of Traditional Chinese Medicine, vol. 49, no. 12, pp. 1081–1083.
  48. S.-Y. Yi, K.-J. Nan, S.-J. Chen et al., “Effect of extract of Ginkgo biloba on doxorubicin-associated cardiotoxicity in patients with breast cancer,” Chinese Journal of Integrated Traditional and Western Medicine, vol. 28, no. 1, pp. 68–70, 2008. View at Google Scholar · View at Scopus
  49. W. H. Zhang, C. Y. Zhao, X. F. Zhang et al., “Effect of radix astragali taohong decoction on dellular immune function in breast cancer patients with postoperative chemotherapy,” Chinese Journal of Breast Disease, vol. 2, no. 4, pp. 137–143.
  50. Y. C. Zhang, X. J. Li, Y. J. Jia, J. Chen, and Y. Y. Sun, “Clinical observation of “Fuzheng Quyu Jiedu Prescription” combining with chemotherapy in treating postoperative breast cancer,” Shanghai Journal of Traditional Chinese Medicine, vol. 45, no. 11, pp. 64–66, 2011. View at Google Scholar
  51. X. Y. Zhang and G. C. Li, “Clinical study of Tiaogan Lipi method combined with Neoadjuvan chemotherapy for the treatment of breast cancer,” Modern Practical Medicine, vol. 25, no. 10, pp. 1145–1146.
  52. R. Zhong, Clinical Rearch of Shu Gan Tiao Li Chong Ren Decoction with the Chemotherapy in the Treatment of Breast Cancer's QOL, The First Clinical Medical College, Nanjing University of Chinese Medicine, 2009.
  53. M. P. Coleman, “Trends in breast cancer incidence, survival, and mortality,” The Lancet, vol. 356, no. 9229, pp. 590–593, 2000. View at Publisher · View at Google Scholar · View at Scopus
  54. A. Glaus, B. Fäh, R. Hornung, H. Senn, and F. Stiefel, “Breast cancer prevention behaviour: a perspective of women from three language regions of Switzerland,” Pflege, vol. 17, no. 6, pp. 385–394, 2004. View at Publisher · View at Google Scholar · View at Scopus
  55. L. Lohr, “Chemotherapy-induced nausea and vomiting,” Cancer Journal, vol. 14, no. 2, pp. 85–93, 2008. View at Publisher · View at Google Scholar · View at Scopus
  56. S. Hori, I. Mihaylov, J. C. Vasconcelos, and M. McCoubrie, “Patterns of complementary and alternative medicine use amongst outpatients in Tokyo, Japan,” BMC Complementary and Alternative Medicine, vol. 8, article 14, 2008. View at Publisher · View at Google Scholar · View at Scopus
  57. H.-J. Seo, S.-M. Baek, S. G. Kim, T.-H. Kim, and S. M. Choi, “Prevalence of complementary and alternative medicine use in a community-based population in South Korea: a systematic review,” Complementary Therapies in Medicine, vol. 21, no. 3, pp. 260–271, 2013. View at Publisher · View at Google Scholar · View at Scopus
  58. L. L. D. Zhong, H.-Y. Chen, W. C. S. Cho, X.-M. Meng, and Y. Tong, “The efficacy of Chinese herbal medicine as an adjunctive therapy for colorectal cancer: a systematic review and meta-analysis,” Complementary Therapies in Medicine, vol. 20, no. 4, pp. 240–252, 2012. View at Publisher · View at Google Scholar · View at Scopus
  59. F. Cheung, “TCM: made in China,” Nature, vol. 480, no. 7378, pp. S82–S83, 2011. View at Publisher · View at Google Scholar · View at Scopus
  60. A. Bensoussan, N. J. Talley, M. Hing, R. Menzies, A. Guo, and M. Ngu, “Treatment of irritable bowel syndrome with Chinese herbal medicine: a randomized controlled trial,” The Journal of the American Medical Association, vol. 280, no. 18, pp. 1585–1589, 1998. View at Publisher · View at Google Scholar · View at Scopus
  61. D. C. Cherkin, K. J. Sherman, A. L. Avins et al., “A randomized trial comparing acupuncture, simulated acupuncture, and usual care for chronic low back pain,” Archives of Internal Medicine, vol. 169, no. 9, pp. 858–866, 2009. View at Publisher · View at Google Scholar · View at Scopus
  62. A. T. Lathia, S. M. Jung, and L. X. Chen, “Efficacy of acupuncture as a treatment for chronic shoulder pain,” Journal of Alternative and Complementary Medicine, vol. 15, no. 6, pp. 613–618, 2009. View at Publisher · View at Google Scholar · View at Scopus
  63. E. A. Macklin, P. M. Wayne, L. A. Kalish et al., “Stop Hypertension with the Acupuncture Research Program (SHARP): results of a randomized, controlled clinical trial,” Hypertension, vol. 48, no. 5, pp. 838–845, 2006. View at Publisher · View at Google Scholar · View at Scopus
  64. W. C. S. Cho and H.-Y. Chen, “Clinical efficacy of traditional chinese medicine as a concomitant therapy for nasopharyngeal carcinoma: a systematic review and meta-analysis,” Cancer Investigation, vol. 27, no. 3, pp. 334–344, 2009. View at Publisher · View at Google Scholar · View at Scopus
  65. S. G. Li, H. Y. Chen, C. S. Ou-Yang et al., “The efficacy of chinese herbal medicine as an adjunctive therapy for advanced non-small cell lung cancer: a systematic review and meta-analysis,” PLoS ONE, vol. 8, no. 2, Article ID e57604, 2013. View at Publisher · View at Google Scholar · View at Scopus
  66. P. Wu, J. J. Dugoua, O. Eyawo, and E. J. Mills, “Traditional Chinese medicines in the treatment of hepatocellular cancers: a systematic review and meta-analysis,” Journal of Experimental and Clinical Cancer Research, vol. 28, article 112, 2009. View at Publisher · View at Google Scholar · View at Scopus
  67. W. Kim, W.-B. Lee, J.-W. Lee et al., “Traditional herbal medicine as adjunctive therapy for breast cancer: a systematic review,” Complementary Therapies in Medicine, vol. 23, no. 4, pp. 626–6232, 2015. View at Publisher · View at Google Scholar
  68. N. E. Haddad and O. Palesh, “Acupuncture in the treatment of cancer-related psychological symptoms,” Integrative Cancer Therapies, vol. 13, no. 5, pp. 371–385, 2014. View at Publisher · View at Google Scholar · View at Scopus
  69. E. Ernst, K. Schmidt, and M. Baum, “Complementary/alternative therapies for the treatment of breast cancer. A systematic review of randomized clinical trials and a critique of current terminology,” Breast Journal, vol. 12, no. 6, pp. 526–530, 2006. View at Publisher · View at Google Scholar · View at Scopus