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Evidence-Based Complementary and Alternative Medicine
Volume 2016, Article ID 3410213, 9 pages
Research Article

Effect and Safety of Shihogyejitang for Drug Resistant Childhood Epilepsy

1Department of Pediatric Neurology of Korean Medicine, I-Tomato Hospital, Seoul, Republic of Korea
2College of Korean Medicine, Gachon University, Seongnam, Republic of Korea

Received 16 October 2015; Revised 28 December 2015; Accepted 7 February 2016

Academic Editor: Sunoh Kwon

Copyright © 2016 Jinsoo Lee et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Objective. Herbal medicine has been widely used to treat drug resistant epilepsy. Shihogyejitang (SGT) has been commonly used to treat epilepsy. We investigated the effect and safety of SGT in children with drug resistant epilepsy. Design. We reviewed medical records of 54 patients with epilepsy, who failed to respond to at least two antiepileptic drugs and have been treated with SGT between April 2006 and June 2014 at the Department of Pediatric Neurology, I-Tomato Hospital, Korea. Effect was measured by the response rate, seizure-free rate, and retention rate at six months. We also checked adverse events, change in antiepileptic drugs use, and the variables related to the outcome. Results. Intent-to-treat analysis showed that, after six months, 44.4% showed a >50% seizure reduction, 24.1% including seizure-free, respectively, and 53.7% remained on SGT. Two adverse events were reported, mild skin rash and fever. Focal seizure type presented significantly more positive responses when compared with other seizure types at six months (, Fisher’s exact test). Conclusion. SGT is an effective treatment with excellent tolerability for drug resistant epilepsy patients. Our data provide evidence that SGT may be used as alternative treatment option when antiepileptic drug does not work in epilepsy children.