Significant Modules and Biological Processes between Active Components of Salvia miltiorrhiza Depside Salt and Aspirin

Table 1

Top 10 overlapping biological functions of the 32 overlapping genes related to active components of S. miltiorrhiza depside salt and aspirin.

GO terms	value	Gene
GO:0042221: response to chemical stimulus		XDH, TNF, MCL1, IL8, PTGS2, RELA, EDN1, SOD1, MMP2, TGFB1, CCL11, MAPK1, CASP3, CCR3, JUN, BCL2, SERPINE1, IFNG, IL1B, NOS3, MAPK8, ALOX5, NOS2, and IKBKB
GO:0006950: response to stress		TNF, PTGER3, IL8, PTGS2, RELA, EDN1, NFKB1, SOD1, MMP2, TGFB1, CCL11, MAPK1, CASP3, CCR3, JUN, BCL2, AKR1B1, SERPINE1, IFNG, IL1B, NOS3, MAPK8, ALOX5, and NOS2
GO:0051704: multiorganism process		TNF, PTGS2, RELA, SOD1, MMP1, TGFB1, CCL11, VCAM1, MAPK1, APP, CCR3, JUN, BCL2, IFNG, IL1B, NOS3, and NOS2
GO:0050896: response to stimulus		XDH, TNF, MCL1, PTGS2, EDN1, NFKB1, MMP2, TGFB1, CASP3, APP, BCL2, SERPINE1, IFNG, IL1B, NOS3, NOS2, PTGER3, IL8, RELA, SOD1, CCL11, MAPK1, CCR3, JUN, AKR1B1, MAPK8, ALOX5, and IKBKB
GO:0009605: response to external stimulus		TNF, PTGER3, IL8, PTGS2, RELA, NFKB1, SOD1, TGFB1, CCL11, MAPK1, CASP3, CCR3, JUN, BCL2, IFNG, SERPINE1, IL1B, and ALOX5
GO:0042127: regulation of cell proliferation		PTGER2, TNF, IL8, PTGS2, RELA, EDN1, TGFB1, VCAM1, MAPK1, CASP3, JUN, BCL2, IFNG, SERPINE1, IL1B, NOS3, and NOS2
GO:0042981: regulation of apoptosis		TNF, PTGS2, MCL1, RELA, NFKB1, SOD1, TGFB1, MAPK1, APP, CASP3, JUN, BCL2, IFNG, IL1B, NOS3, MAPK8, and IKBKB
GO:0043067: regulation of programmed cell death		TNF, PTGS2, MCL1, RELA, NFKB1, SOD1, TGFB1, MAPK1, APP, CASP3, JUN, BCL2, IFNG, IL1B, NOS3, MAPK8, and IKBKB
GO:0010941: regulation of cell death		TNF, PTGS2, MCL1, RELA, NFKB1, SOD1, TGFB1, MAPK1, APP, CASP3, JUN, BCL2, IFNG, IL1B, NOS3, MAPK8, and IKBKB
GO:0065008: regulation of biological quality		XDH, TNF, PTGER3, PTGS2, MCL1, EDN1, SOD1, TGFB1, CCL11, CASP3, APP, CCR3, JUN, BCL2, IFNG, SERPINE1, IL1B, NOS3, NOS2, and IKBKB