Hydroalcoholic Extract from Inflorescences of Achyrocline satureioides (Compositae) Ameliorates Dextran Sulphate Sodium-Induced Colitis in Mice by Attenuation in the Production of Inflammatory Cytokines and Oxidative Mediators
Table 5
Effects of HEAS on MPO and SOD activity and on GSH and LOOH levels in colon tissue of DSS-induced colitic mice.
Treatment
Dose (mg/kg, p.o)
MPO (mD.O/mg of protein)
SOD (U/mg of tissue)
GSH (µg/mg of tissue)
LOOH (mmol/mg of tissue)
Non-colitic
Vehicle
—
1.15 ± 0.50
1.36 ± 0.22
797.50 ± 111.10
2.03 ± 0.58
Colitic
Vehicle
—
4.24 ± 0.71
0.15 ± 0.03
454.70 ± 78.24
3.99 ± 0.60
Colitic
5-ASA
100
3.80 ± 0.24
1.10 ± 0.10
424.78 ± 59.28
4.02 ± 0.29
Colitic
HEAS
10
2.96 ± 0.11
1.35 ± 0.04
444.12 ± 18.42
3.52 ± 0.42
Colitic
HEAS
100
1.26 ± 0.36
1.36 ± 0.64
482.70 ± 62.52
4.14 ± 0.34
versus non-colitic vehicle group, versus colitic vehicle group.
