Acute and Subchronic Oral Toxicity Evaluation of Aqueous Root Extract of Dicoma anomala Sond. in Wistar Rats
Table 1
Effect of oral administration of aqueous extract of Dicoma anomala for 90 days on relative organ-to-body weight ratio of male Wistar rats.
Organ
Dose (mg/kg/day)
Control
125
250
500
Initial weight
122.60 ± 2.55
123.00 ± 2.94
117.60 ± 4.09
106.60 ± 5.17
Body weight
234.50 ± 6.92
394.20 ± 17.77
371.10 ± 15.08
342.60 ± 4.70
% weight change
91.27
220.48
215.56
221.39
Liver
5.27 ± 0.19
9.63 ± 0.95
10.22 ± 0.23
8.22 ± 0.39
Brain
1.23 ± 0.05
1.35 ± 0.05
1.28 ± 0.22
3.17 ± 0.16
Heart
0.82 ± 0.03
1.42 ± 0.03
1.42 ± 0.06
1.22 ± 0.12
Lungs
2.02 ± 0.36
3.26 ± 0.62
3.39 ± 0.32
1.95 ± 0.20
Kidney
1.69 ± 0.18
2.45 ± 0.28
2.45 ± 0.10
2.22 ± 0.16
Spleen
0.46 ± 0.03
0.62 ± 0.08
0.69 ± 0.02
0.60 ± 0.07
Stomach
2.65 ± 0.12
2.94 ± 0.44
3.02 ± 0.52
3.17 ± 0.05
Testes
3.16 ± 0.12
4.58 ± 1.16
3.41 ± 0.21
3.33 ± 0.25
Pancreas
0.96 ± 0.03
1.52 ± 0.01
1.64 ± 0.26
1.36 ± 0.18
Liver
2.25
2.44
2.75
2.4
Brain
0.52
0.34
0.34
0.93
Heart
0.35
0.36
0.38
0.36
Lungs
0.86
0.83
0.91
0.57
Kidney
0.72
0.62
0.66
0.65
Spleen
0.20
0.16
0.19
0.18
Stomach
1.13
0.75
0.81
0.93
Testes
1.35
1.16
0.92
0.97
Pancreas
0.41
0.39
0.44
0.40
Mean organ-to-body weight ratio was calculated and expressed as mean ± SEM (). Unit: g. Unit: % body weight. Statistically significant compared to control ().
