Acute and Subchronic Oral Toxicity Evaluation of Aqueous Root Extract of Dicoma anomala Sond. in Wistar Rats

Table 5

Effect of aqueous root extracts of Dicoma anomala for 90 days on biochemical parameters of male Wistar rats.

Parameters	Unit	Dose (mg/kg/day)
		Control	125	250	500
Total cholesterol	mmol/L	2.50 ± 0.23	2.10 ± 0.15	2.20 ± 0.13	2.00 ± 0.20
Triglycerides	mmol/L	0.65 ± 0.00	1.21 ± 0.11	0.87 ± 0.20	0.86 ± 0.01
HDL-c	mmol/L	1.60 ± 0.23	1.30 ± 0.17	1.40 ± 0.25	1.30 ± 0.19
LDL-c	mmol/L	0.90 ± 0.00	0.80 ± 0.11	0.80 ± 0.14	0.70 ± 0.50
ALT	U/L	51.00 ± 0.85	48.00 ± 0.55	47.00 ± 0.77	47.00 ± 0.74
AST	U/L	215.00 ± 0.85	188.00 ± 0.90	145.00 ± 0.87	192.00 ± 0.88
ALP	U/L	185.00 ± 0.87	200.00 ± 0.90	264.00 ± 0.47	220.00 ± 0.75
Glucose	mg/dL	4.23 ± 0.10	3.70 ± 0.11	4.27 ± 0.05	4.47 ± 0.23
Sodium	mmol/L	137.00 ± 0.67	141.00 ± 0.85	142.00 ± 0.44	142.00 ± 0.53
Potassium	mmol/L	5.40 ± 0.01	5.20 ± 0.01	4.80 ± 0.02	5.60 ± 0.00
Chloride	mmol/L	104.00 ± 0.11	103.00 ± 0.21	104.00 ± 0.12	104.00 ± 0.01
Calcium	mmol/L	2.38 ± 0.01	2.31 ± 0.10	2.32 ± 0.14	2.34 ± 0.20
Magnesium	mmol/L	0.99 ± 0.40	0.87 ± 0.02	0.95 ± 0.14	0.88 ± 0.01
Urea	mmol/L	8.10 ± 0.01	7.50 ± 0.00	7.90 ± 0.12	7.50 ± 0.24
Creatinine	µmol/L	44.00 ± 0.23	41.00 ± 0.21	40.00 ± 0.17	35.00 ± 0.20
Albumin	g/L	34.00 ± 0.15	32.00 ± 0.20	31.00 ± 0.10	32.00 ± 0.05
Total protein	g/L	65.00 ± 0.3	65.00 ± 0.25	63.00 ± 0.33	64.00 ± 2.0
Total bilirubin	µmol/L	3.00 ± 0.11	3.00 ± 0.12	2.00 ± 0.00	2.00 ± 0.15
Conj. bilirubin	µmol/L	1.00 ± 0.1	1.00 ± 0.01	1.00 ± 0.10	1.00 ± 0.01
Unconj. bilirubin	µmol/L	2.00 ± 0.01	2.00 ± 0.01	1.00 ± 0.00	1.00 ± 0.00

Values are presented as mean ± SEM ().
Significantly different compared to control at .