Research Article
Acute and Subchronic Oral Toxicity Evaluation of Aqueous Root Extract of Dicoma anomala Sond. in Wistar Rats
Table 5
Effect of aqueous root extracts of Dicoma anomala for 90 days on biochemical parameters of male Wistar rats.
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Parameters | Unit | Dose (mg/kg/day) |
Control | 125 | 250 | 500 |
| Total cholesterol | mmol/L | 2.50 ± 0.23 | 2.10 ± 0.15 | 2.20 ± 0.13 | 2.00 ± 0.20 | Triglycerides | mmol/L | 0.65 ± 0.00 | 1.21 ± 0.11 | 0.87 ± 0.20 | 0.86 ± 0.01 | HDL-c | mmol/L | 1.60 ± 0.23 | 1.30 ± 0.17 | 1.40 ± 0.25 | 1.30 ± 0.19 | LDL-c | mmol/L | 0.90 ± 0.00 | 0.80 ± 0.11 | 0.80 ± 0.14 | 0.70 ± 0.50 | ALT | U/L | 51.00 ± 0.85 | 48.00 ± 0.55 | 47.00 ± 0.77 | 47.00 ± 0.74 | AST | U/L | 215.00 ± 0.85 | 188.00 ± 0.90 | 145.00 ± 0.87 | 192.00 ± 0.88 | ALP | U/L | 185.00 ± 0.87 | 200.00 ± 0.90 | 264.00 ± 0.47 | 220.00 ± 0.75 | Glucose | mg/dL | 4.23 ± 0.10 | 3.70 ± 0.11 | 4.27 ± 0.05 | 4.47 ± 0.23 | Sodium | mmol/L | 137.00 ± 0.67 | 141.00 ± 0.85 | 142.00 ± 0.44 | 142.00 ± 0.53 | Potassium | mmol/L | 5.40 ± 0.01 | 5.20 ± 0.01 | 4.80 ± 0.02 | 5.60 ± 0.00 | Chloride | mmol/L | 104.00 ± 0.11 | 103.00 ± 0.21 | 104.00 ± 0.12 | 104.00 ± 0.01 | Calcium | mmol/L | 2.38 ± 0.01 | 2.31 ± 0.10 | 2.32 ± 0.14 | 2.34 ± 0.20 | Magnesium | mmol/L | 0.99 ± 0.40 | 0.87 ± 0.02 | 0.95 ± 0.14 | 0.88 ± 0.01 | Urea | mmol/L | 8.10 ± 0.01 | 7.50 ± 0.00 | 7.90 ± 0.12 | 7.50 ± 0.24 | Creatinine | µmol/L | 44.00 ± 0.23 | 41.00 ± 0.21 | 40.00 ± 0.17 | 35.00 ± 0.20 | Albumin | g/L | 34.00 ± 0.15 | 32.00 ± 0.20 | 31.00 ± 0.10 | 32.00 ± 0.05 | Total protein | g/L | 65.00 ± 0.3 | 65.00 ± 0.25 | 63.00 ± 0.33 | 64.00 ± 2.0 | Total bilirubin | µmol/L | 3.00 ± 0.11 | 3.00 ± 0.12 | 2.00 ± 0.00 | 2.00 ± 0.15 | Conj. bilirubin | µmol/L | 1.00 ± 0.1 | 1.00 ± 0.01 | 1.00 ± 0.10 | 1.00 ± 0.01 | Unconj. bilirubin | µmol/L | 2.00 ± 0.01 | 2.00 ± 0.01 | 1.00 ± 0.00 | 1.00 ± 0.00 |
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Values are presented as mean ± SEM (). Significantly different compared to control at .
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