Acute and Subchronic Oral Toxicity Evaluation of Aqueous Root Extract of Dicoma anomala Sond. in Wistar Rats

Table 6

Effect of aqueous root extracts of Dicoma anomala for 90 days on biochemical parameters of female Wistar rats.

Parameters	Unit	Dose (mg/kg/day)
		Control	125	250	500
Total cholesterol	mmol/L	2.30 ± 0.23	2.00 ± 0.15	2.20 ± 0.13	2.10 ± 0.20
Triglycerides	mmol/L	0.56 ± 0.00	0.67 ± 0.11	0.85 ± 0.20	0.89 ± 0.01
HDL-c	mmol/L	1.65 ± 0.23	1.15 ± 0.17	1.30 ± 0.25	1.30 ± 0.19
LDL-c	mmol/L	0.80 ± 0.00	0.70 ± 0.11	0.70 ± 0.14	0.60 ± 0.50
ALT	U/L	49.00 ± 0.85	46.00 ± 0.55	45.00 ± 0.77	45.00 ± 0.74
AST	U/L	210.00 ± 0.85	178.00 ± 0.90	150.00 ± 0.87	182.00 ± 0.88
ALP	U/L	165.00 ± 0.87	170.00 ± 0.90	235.00 ± 0.47	210.00 ± 0.75
Glucose	mg/dL	3.23 ± 0.10	3.10 ± 0.11	4.29 ± 0.05	4.74 ± 0.23
Sodium	mmol/L	107.00 ± 0.67	115.00 ± 0.85	123.00 ± 0.44	144.00 ± 0.53
Potassium	mmol/L	5.49 ± 0.01	5.29 ± 0.01	4.99 ± 0.02	5.61 ± 0.00
Chloride	mmol/L	107.00 ± 0.11	106.00 ± 0.21	107.00 ± 0.12	107.00 ± 0.01
Calcium	mmol/L	2.32 ± 0.67	2.30 ± 0.10	2.31 ± 0.14	2.33 ± 0.20
Magnesium	mmol/L	0.80 ± 0.40	0.82 ± 0.02	0.85 ± 0.14	0.88 ± 0.01
Urea	mmol/L	7.99 ± 0.01	7.65 ± 0.00	7.89 ± 0.12	8.05 ± 0.24
Creatinine	µmol/L	43.00 ± 0.23	40.00 ± 0.21	40.00 ± 0.17	37.00 ± 0.20
Albumin	g/L	35.00 ± 0.15	33.00 ± 0.20	32.00 ± 0.10	34.00 ± 0.05
Total protein	g/L	65.00 ± 0.3	65.00 ± 0.25	65.00 ± 0.33	64.00 ± 2.0
Total bilirubin	µmol/L	2.00 ± 0.11	2.00 ± 0.12	3.00 ± 0.00	3.00 ± 0.15
Conj. bilirubin	µmol/L	1.00 ± 0.1	1.00 ± 0.01	1.00 ± 0.10	1.00 ± 0.01
Unconj. bilirubin	µmol/L	2.00 ± 0.01	2.00 ± 0.01	1.00 ± 0.00	1.00 ± 0.00

Values are presented as mean ± SEM ().
Significantly different compared to control at .