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| Isolates | Fractions | | |
References | Miura, et al., 2001 [26] | Kavishankar and Lakshmidevi, 2014 [27] | Moser et al., 2014 [28] | Chen et al., 2009 [38] | Ruan et al., 2012 [29] | Sato et al., 2002 [30] | Lo et al., 2006 [31] | Yoshida et al., 2013 [32] | Zhao et al., 2014 [34] | Kumar et al., 2012 [40] | Luo et al., 1999 [36] | Perez-Gutierrez and Damian-Guzman, 2012 [35] | Kwon et al., 2012 [37] | Krenisky et al., 1999 [33] | Hsu et al., 2014 [39] | Ren et al., 2015 [25] | Agrawal et al., 2013 [42] | Zhang et al., 2013 [41] | Jeong and Song, 2011 [1] | Chakrabarti et al., 2005 [44] | Paramaguru et al., 2014 [43] | Kiho et al., 2001 [45] | Fujii et al., 2009 [46] | Chen et al., 2013 [47] | Arya et al., 2012 [49] | Klomann et al., 2010 [48] | Arya et al., 2012 [49] | Xu et al., 2015 [17] | Ibrahim and Islam, 2014 [50] | Ganeshpurkar et al., 2014 [51] | Shu et al., 2009 [52] | Zhao et al., 2005 [54] | Hwang et al., 2009 [55] | Wu et al., 2005 [56] | Xu et al., 2011 [57] | Costantino et al., 2003 [58] | Yu et al., 2015 [61] | Kharbanda et al., 2014 [60] | Roman-Ramos et al., 2012 [53] | | |
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Accurate and concise description of the content of the article | | X | X | X | X | X | X | X | X | X | X | | X | X | | X | X | | | X | X | | X | X | X | X | X | X | X | X | X | X | X | X | X | X | X | X | X | 33 | 84.62% |
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Abstract | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
Summary of the background, research objectives, methods, main findings, and conclusions | X | X | X | X | X | | X | X | X | X | X | X | X | X | X | X | X | X | X | | | X | X | X | X | X | X | X | X | X | X | X | X | X | X | X | X | X | X | 36 | 92.30% |
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Introduction | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
Sufficient scientific background | X | X | X | X | X | | X | X | X | X | | X | X | X | X | X | X | X | X | X | X | X | X | X | X | X | X | X | X | X | X | X | X | X | X | X | X | X | X | 37 | 94.87% |
Explanation of the experimental approach and rationale | | X | X | X | X | X | X | X | X | X | X | X | X | X | X | X | X | X | X | X | X | X | X | X | X | X | X | X | X | X | X | X | X | X | X | X | X | | X | 37 | 94.87% |
Objectives | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
Clear primary and second objectives | X | X | X | X | | | X | X | X | X | X | | X | X | X | X | X | X | | X | X | X | X | | | X | X | X | X | X | X | X | X | X | | X | X | X | X | 32 | 82.05% |
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Material and methods | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
Ethical statement | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
Nature of the ethical review permissions and institutional guidelines for the care and use of animals | | X | X | X | X | X | X | X | X | X | X | X | X | X | X | X | X | X | X | | X | X | | X | X | X | X | X | X | X | X | X | X | X | X | X | X | X | X | 36 | 92.3% |
Study design | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
Number of animals per group | | X | X | X | | | X | X | X | X | X | X | X | X | | X | | | | X | X | | | X | X | X | X | X | X | X | | X | X | X | X | X | X | X | X | 29 | 74.35% |
Information on whether the experiment was performed as a blind controlled study | | | | | X | | | X | | | | | | | | | | | | | | | X | | | | X | | | | | | X | | | | X | | | 6 | 15.38% |
Experimental procedures | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
Treatment | X | X | X | X | X | X | X | X | X | X | X | X | X | X | X | X | X | X | X | X | X | X | X | X | X | X | X | X | X | X | X | X | X | X | X | X | X | X | X | 39 | 100.00% |
Dosage of treatment | X | X | X | X | X | X | X | X | X | X | X | X | | X | X | X | X | X | X | X | X | X | X | | X | X | X | X | X | X | X | X | X | X | X | X | X | X | X | 37 | 94.87% |
Route of administration | X | X | X | X | X | X | X | X | X | X | X | X | X | X | X | X | X | | X | X | X | X | X | X | X | X | X | X | X | X | X | X | X | X | X | X | X | X | X | 38 | 97.44% |
Duration of treatment | X | X | X | X | | X | X | | | X | X | X | | X | X | X | X | X | X | X | X | X | X | X | X | X | X | X | X | X | X | X | X | X | X | X | X | X | X | 35 | 89.74% |
Time of day for treatment administration | | X | | | | | | | | | | X | | | | | | X | X | X | | | X | X | | | | | | | X | | | | | X | | | | 9 | 23.07% |
Location used for administration of treatment | | | | | | | | | | | | | | | | | | | | | | | | | | | | X | | | | | | | | | | | | 1 | 2.56% |
Rationale for choice of specific dosage | | | | | X | | X | | X | | | X | X | | X | | | | | X | X | | X | | | | | | | | | | X | | | X | | | X | 12 | 30.76% |
Rationale for choice of specific route of administration | | | | | X | | X | | X | | | | | | | | | | | | | | | | | | | | | | | | | | | X | | X | X | 6 | 15.38% |
Experimental animals | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
Information on animal species | X | X | X | X | X | X | X | X | X | X | X | X | X | X | | X | X | X | X | X | X | X | X | X | X | X | X | X | X | X | X | X | X | X | | | X | X | | 35 | 89.74% |
Strain of the animals | | X | | | X | X | X | X | X | X | X | | X | | | X | X | X | X | X | X | X | X | X | X | X | | | X | X | X | X | X | X | | | X | X | X | 29 | 74.36% |
Sex of the animals | X | X | X | X | X | X | X | X | X | X | X | X | X | X | X | X | X | X | | X | X | X | X | X | X | X | X | X | X | X | | X | X | X | | X | X | X | X | 36 | 92.30% |
Animals weight range | | X | | | | | X | | | | | X | | X | | X | X | X | | X | X | X | | X | X | | X | X | X | | X | X | X | X | | | X | X | X | 22 | 56.41% |
Age of the animals | X | | X | X | X | X | | | X | | X | | X | X | X | X | | | X | X | | X | X | | X | X | | | X | | | | X | X | X | | X | | | 22 | 56.41% |
Description of genetic modification status (knock-out, transgenic, and SPF) | X | | X | X | | | | | X | X | X | | | | X | | | X | X | | | X | X | | | | | X | | | | | X | X | | X | X | X | X | 18 | 46.15% |
Information related to previous procedures performed on the animals | | X | X | X | X | X | X | X | | | X | X | X | X | X | | | X | X | X | X | X | X | X | X | | X | | | | | | | X | | | X | X | X | 25 | 64.10% |
Housing and husbandry | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
Housing of experimental animals (type of facility, type of cage or housing, material, and number of cage companions) | | | X | | | | X | X | | | X | X | X | | | X | | | X | | X | | | | | X | X | X | X | | | | | | | | X | | | 14 | 35.89% |
Husbandry conditions (breeding programme, light/dark cycle, and temperature of water) | | X | X | X | X | | X | X | | X | X | X | X | X | X | X | X | | X | X | X | X | X | X | X | X | X | X | X | X | X | X | X | X | X | | X | | X | 33 | 84.62% |
Welfare-related assessments and interventions that were carried out before, during, or after the experiment | | | | | | | X | | | | | | | | | | | | | X | X | | X | | | | | | | | | | | | | | X | | | 5 | 12.82% |
Sample size | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
Total number of animals used in each experiment and the number of animals in each experimental group | | X | X | X | | | X | X | X | X | | X | X | | | X | | | | | X | | X | X | X | X | X | X | X | X | | X | | | X | | X | | | 22 | 56.41% |
Explanation regarding the decision of the number of animals and details of sample size calculation | | | | | | | X | | | | | | | | | | | | | | | | | | | | | | | | | | X | | | | | | | 2 | 5.12% |
Allocation of animals into experimental groups | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
Full details of how animals were allocated to experimental groups (including randomization or matching) | | | | X | | | X | | X | | | | X | | | | | X | | | | | X | | X | | | X | X | | | X | | | | | X | | | 11 | 28.20% |
Order in which the animals in the different experimental groups were treated and assessed | X | X | X | X | X | | X | X | X | | X | X | | | | | | X | X | X | X | X | X | X | X | X | X | X | | X | | | X | X | X | | X | X | X | 28 | 71.79% |
Experimental outcomes | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
Clear experimental outcomes assessed | | X | X | X | X | | X | X | X | X | X | X | | X | | | | | | | X | X | X | X | X | X | X | X | X | X | X | X | X | X | | | X | X | X | 28 | 71.79% |
Statistical methods | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
Statistical methods used for each analysis | X | X | X | X | X | | X | X | X | X | | | X | X | X | X | X | X | X | X | X | X | X | X | X | X | X | X | X | | X | X | X | X | X | | X | X | X | 34 | 87.18% |
Specification of the unit of analysis for each dataset | | | | X | X | | X | X | X | X | | X | X | X | X | X | X | X | X | X | X | X | X | X | X | X | X | X | X | X | X | X | X | X | X | | X | X | X | 33 | 84.61% |
Methods used to assess whether the data met the assumptions of the statistical approach | X | X | X | X | X | | X | X | X | X | | X | X | X | | X | X | X | X | X | X | X | X | X | X | X | X | X | X | X | X | X | X | X | | | X | X | X | 34 | 87.18% |
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Results | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
Baseline data | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
Description of the animals health status, for each experimental group, before treatment | X | X | X | X | | | | | X | X | | | | | | | | X | X | X | X | X | X | X | | | X | | X | | | X | | X | | | X | | | 18 | 46.15% |
Number analyzed | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
Number or animals in each group included in each analysis (absolute numbers) | | | | | | | X | X | | X | | | | | | X | | | | | | | | | | X | X | | X | | | X | X | X | | | X | | X | 12 | 30.76% |
Animals or data not included in the analysis (and explanation for the exclusion) | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | X | | | | | | 1 | 2.56% |
Outcomes and estimation | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
Information (mean = standard deviation) | X | X | X | X | X | | | | | | | X | X | | | | | X | X | X | X | X | X | X | X | | | | | | | | X | X | | | X | X | X | 20 | 51.28% |
Information on quantification of inflammatory cells (mean = standard deviation) | | | | | | | | | | | | | | | | | | | | | | | | X | | | | | | | | | | | | | | | | 1 | 2.56% |
Adverse events | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
Information on mortality of experimental animal (mean = standard deviation) | | | X | | | | | | | | | | | | | | | | | | X | | | | | | | | | | | X | | | | | | | | 3 | 7.69% |
Modifications to the experimental protocols made to reduce adverse events | | | X | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | X | | | 2 | 5.12% |
Discussion | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
Interpretation/scientific implications | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
Interpretation of the results, taking into account the study objectives and hypotheses | X | X | X | X | | X | X | X | X | X | X | X | X | X | X | | X | X | X | X | X | X | X | X | X | X | X | X | X | X | X | X | X | X | | | X | X | X | 35 | 89.74% |
Comments on the study limitations (sources of bias and imprecision associated with the results) | | X | X | | | X | X | | X | X | | | | | | | | | | X | | | | | | | | | | | | | X | X | | | X | X | X | 12 | 30.76% |
Generalizability /translation | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
Comments on how the findings are likely to translate to other species or systems (relevance to human biology) | | | X | X | X | X | X | X | X | X | | X | X | | X | X | X | X | | | | | X | | | X | X | | | | | | X | X | | | X | X | X | 22 | 56.41% |
Funding | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
List of funding sources and the role of the funder(s) in the study | | X | X | X | | | | | | X | | | X | X | X | X | X | | X | X | X | | X | X | X | X | X | X | X | X | X | X | X | X | | X | X | X | X | 28 | 71.79% |
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Results | 17 | 28 | 31 | 29 | 24 | 15 | 33 | 26 | 28 | 27 | 23 | 25 | 27 | 23 | 20 | 24 | 21 | 24 | 22 | 27 | 29 | 25 | 32 | 27 | 27 | 27 | 29 | 27 | 28 | 22 | 21 | 25 | 32 | 32 | 16 | 17 | 38 | 26 | 30 | | |
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