CHM Sex/age (y) Usage and dosage Exposure ALT (IU/L)/AST (IU/L)/ Pattern RUCAM grade (scores) Outcome Reexposure Countries Sheng-He-Shou-Wu M/45 1 kg soaked in 2.5 kg wine, 25 mL/day 7 d 2870/2599/2.26/109 Hepatocellular Highly probable (13) Recovery NA China Sheng-He-Shou-Wu M/63 1 kg soaked in 22 kg wine, 250 mL/day 15 d 601/1515/2.87/181 Hepatocellular Highly probable (11) Recovery NA China He-Shou-Wu M/29 100 g consumed as tea, 100 mL/day 29 d 1792/899/5.51/138 Hepatocellular Highly probable (11) Recovery NA China He-Shou-Wu M/40 1 kg soaked in 10 kg wine, 300 mL/day 28 d 878/853/7.47/112 Hepatocellular Highly probable (10) Recovery NA China He-Shou-Wu M/40 1 kg soaked in 20 kg alcohol, 50 mL/day 43 d 4095/2473/1.7/220 Hepatocellular Highly probable (10) Recovery NA China He-Shou-Wu M/55 1 kg soaked in 15 kg alcohol, 300 mL/day 4 d 1056/769/10.29/176 Hepatocellular Highly probable (10) Recovery NA China He-Shou-Wu M/61 NA 1 d 818/NA/1.77/109 Hepatocellular Highly probable (10) Recovery Positive Korea He-Shou-Wu M/61 NA 60 d 885/NA/21.2/224 Mixed Highly probable (10) Recovery NA Korea Sheng-He-Shou-Wu M/40 1 kg soaked in 10 kg wine, 200 mL/day 1 d 3120/1615/16.78/151 Hepatocellular Highly probable (10) Recovery NA China Move Free F/78 a recommended dose of 1 tablet twice a day 21 d 1626/1053/7.2/354 Hepatocellular Highly probable (10) Recovery NA USA He-Shou-Wu F/45 Not available 7 d 1196/507/0.88/816 Hepatocellular Highly probable (9) Recovery NA China He-Shou-Wu M/31 10 g powder consumed directly, 20 g/day 14 d 2026/858/2.19/180 Hepatocellular Highly probable (9) Recovery NA China He-Shou-Wu M/56 1 slice consumed as tea, 100 mL/day 120 d 2313/1202/5.81/305 Hepatocellular Highly probable (9) Recovery NA China He-Shou-Wu F/37 1 tablespoon consumed as decoction, 250 mL/day 52 d 922/319/9.06/116 Hepatocellular Highly probable (9) Recovery NA China He-Shou-Wu F/46 1 tablespoon consumed as decoction, 250 mL/day 50 d 1127/297/1.94/203 Hepatocellular Highly probable (9) Recovery NA China He-Shou-Wu F/18 1 tablespoon consumed as decoction, 100 mL/day 67 d 1074/348/0.8/89 Hepatocellular Highly probable (9) Recovery NA China He-Shou-Wu M/40 3 tablespoons consumed as decoction, 100 mL/day 23 d 1987/872/11/182 Hepatocellular Highly probable (9) Recovery NA China He-Shou-Wu M/34 NA 30 d 1452/NA/25.3/111 Hepatocellular Highly probable (9) Recovery NA Korea He-Shou-Wu M/58 NA 35 d 1898/NA/13.4/134 Hepatocellular Highly probable (9) Recovery NA Korea He-Shou-Wu M/45 NA 30 d 1400/NA/2.04/125 Hepatocellular Highly probable (9) Recovery NA Korea He-Shou-Wu M/49 NA 90 d 1235/NA/32.9/465 Mixed Highly probable (9) Recovery NA Korea He-Shou-Wu M/46 NA 2 d 1287/NA/19.7/146 Hepatocellular Highly probable (9) Recovery NA Korea He-Shou-Wu M/62 NA 90 d 1174/NA/9.2/175 Hepatocellular Highly probable (9) Recovery NA Korea He-Shou-Wu F/63 NA 30 d 943/NA/4.2/137 Hepatocellular Highly probable (9) Recovery NA Korea He-Shou-Wu M/44 NA 7 d 1077/NA/15/197 Hepatocellular Highly probable (9) Recovery NA Korea Herbal extracts containing Hu-Ji-Sheng and Ye-Ge M/55 NA 30 d 1528/1108/6.3/160 Hepatocellular Highly probable (9) Recovery NA Korea He-Shou-Wu M/38 2 slices consumed as tea, 500 mL/day 1 d 1815/1351/5.3/108 Hepatocellular Probable (8) Recovery NA China He-Shou-Wu M/48 100 g mixed with 150 g bee honey, 8 g/day 10 d 1891/798/7.9/159 Hepatocellular Probable (8) Recovery NA China He-Shou-Wu F/61 10–20 g/d 60 d 56/61/28.07/601 Cholestatic Probable (8) Recovery NA China He-Shou-Wu M/57 NA 30 d 853/NA/28.1/173 Mixed Probable (8) Death NA Korea He-Shou-Wu F/47 NA 60 d 1947/NA/30.4/218 Hepatocellular Probable (8) Recovery NA Korea He-Shou-Wu M/59 NA 30 d 1245/NA/1.6/155 Hepatocellular Probable (8) Recovery NA Korea He-Shou-Wu F/46 NA 30 d 1804/NA/6.2/81 Hepatocellular Probable (8) Recovery NA Korea He-Shou-Wu M/45 NA 20 d 271/NA/2.9/164 Mixed Probable (8) Recovery NA Korea He-Shou-Wu M/65 NA 10 d 1107/NA/21.9/197 Hepatocellular Probable (8) Recovery NA Korea He-Shou-Wu F/42 NA 10 d 500/NA/1.6/181 Mixed Probable (8) Recovery NA Korea He-Shou-Wu M/42 NA 60 d 1706/NA/26.3/147 Hepatocellular Probable (8) Recovery NA Korea He-Shou-Wu F/48 NA 3 d 1142/NA/15.9/145 Hepatocellular Probable (8) Recovery NA Korea Sheng-He-Shou-Wu M/50 1 kg soaked in 5 kg wine, 500 mL/day 20 d 1992/1155/6.73/185 Hepatocellular Probable (8) Recovery NA China Qi Bao Mei Ran Wan M/26 Taken at the recommended dosages 30 d 1674/617/3.2/normal Hepatocellular Probable (8) Recovery NA China He-Shou-Wu F/41 15 tablets per day 21 d 104/85/21.7/947 Cholestatic Probable (7) Recovery NA China He-Shou-Wu M/37 1 tablespoon consumed as decoction, 1500 mL/day 7 d 1613/835/2.26/177 Hepatocellular Probable (7) Recovery NA China He-Shou-Wu F/54 NA 4 d 1752/NA/8.4/286 Hepatocellular Probable (7) Recovery NA Korea He-Shou-Wu M/24 NA 60 d 1652/NA/31.9/140 Hepatocellular Probable (7) Liver transplantation NA Korea He-Shou-Wu M/42 NA 120 d 1677/NA/15.8/93 Hepatocellular Probable (7) Recovery NA Korea He-Shou-Wu M/41 NA 30 d 520/NA/9.9/143 Mixed Probable (7) Recovery NA Korea Huang-Yao-Zi F/66 30 g decocted in water for oral dose per day 21 d 1042/1006/16.44/normal Hepatocellular Probable (7) Recovery NA China He-Shou-Wu YanShouPian M/17 15 tablets per day 45 d 1501/545/18.63/155 Hepatocellular Probable (6) Recovery NA China He-Shou-Wu F/54 NA 180 d 1519/NA/11.7/187 Hepatocellular Probable (6) Recovery NA Korea He-Shou-Wu/1 M/53 NA 180 d 1227/NA/33.2/370 Mixed Probable (6) Recovery NA Korea Herbal tea containing Kelp F/40 3 cups per day 60 d 435/219/9.2/435 Mixed Probable (6) Recovery NA USA Kamishoyosan F/48 NA 60 d 972/900/12.8/420 Hepatocellular Probable (6) Recovery NA Japan Move Free F/62 4 tablets/d for two and a half weeks tapered down to 2 tablets/d for four days 21 d 1247/893/6.9/297 Hepatocellular Probable (6) Recovery NA USA Decoction [30 ] F/51 Brewed with water, two times a day 23 d 758/1262/9.92/normal Hepatocellular Probable (6) Recovery NA China
