Table of Contents Author Guidelines Submit a Manuscript
Evidence-Based Complementary and Alternative Medicine
Volume 2016, Article ID 3595946, 8 pages
http://dx.doi.org/10.1155/2016/3595946
Research Article

Meta-Analysis of the Clinical Effectiveness and Safety of Ligustrazine in Cerebral Infarction

Chengdu University College of Medicine, Chengdu, China

Received 9 March 2016; Revised 11 July 2016; Accepted 3 August 2016

Academic Editor: I-Min Liu

Copyright © 2016 Tian Yu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. J. Z. Xu, “Status quo of traditional Chinese medicine treatment of cerebral infarction,” Chinese Medicine Mordern Diatance Education of China, vol. 9, no. 4, pp. 192–194, 2011. View at Google Scholar
  2. B. Wu, M. Liu, H. Liu et al., “Meta-analysis of traditional Chinese patent medicine for ischemic stroke,” Stroke, vol. 38, no. 6, pp. 1973–1979, 2007. View at Publisher · View at Google Scholar · View at Scopus
  3. T. Kosuge and H. Kamiya, “Discovery of a pyrazine in a natural product: tetramethylpyrazine from cultures of a strain of Bacillus subtilis,” Nature, vol. 193, p. 776, 1962. View at Publisher · View at Google Scholar · View at Scopus
  4. F. Song, “Research Progress on clinical application of ligustrazine in China in recent ten years,” Strait Pharmaceutical Journal, vol. 26, no. 10, pp. 1–3, 2014. View at Google Scholar
  5. G. F. Hu and J. P. Wang, “The pharmacological action and clinical application progress of Ligustrazine,” Chinese Remedies and Clinics, vol. 16, no. 10, pp. 773–774, 2006. View at Google Scholar
  6. J. E. Zhao, “Study on pharmacological effect of Ligustrazine active ingredients in Chinese medicine Chuanxiong,” Strait Pharmaceutical Journal, vol. 27, no. 8, pp. 145–146, 2015. View at Google Scholar
  7. K. P. Di, X.-C. Jia, R. Qi et al., “Study on the molecular mechanism of ligustrazine inhibiting proliferation of vascular smooth muscle cells,” Chinese Journal of Basic Medicine in Traditional Chinese Medicine, vol. 16, no. 3, pp. 214–216, 2010. View at Google Scholar
  8. M. C. Zhong, X. H. Su, X. Y. Kong, and N. Lin, “Effects of tetramethylpyrazine on migration and tube formation of BMECs,” Chinese Journal of Experimental Traditional Medical Formulae, vol. 21, no. 6, pp. 103–107, 2015. View at Google Scholar
  9. M. H. Liao, C. C. Wu, and M. H. Yen, “Beneficial effects of tetramethylpyrazine, an active constituent of Chinese herbs, on rats with endotoxemia,” Proceedings of the National Science Council, Republic of China—Part B: Life sciences, vol. 22, no. 1, pp. 46–54, 1998. View at Google Scholar · View at Scopus
  10. W.-H. Yang, G.-Q. Gong, Y. Zhou, Z.-X. Zhang, and J. Li, “Effect and mechanism of tetramethylpyrazine on antithrombotic,” Acta Metallurgica Sinica, vol. 17, no. 3, pp. 241–245, 2012. View at Google Scholar
  11. S. L. Tang and Y. L. Gao, “Influence of ligustrazine hydrochloride injection combined Buyang Huanwu Tang to intervention on blood viscosity and coagulation factor with acute cerebral infarction patients,” Chinese Journal of Experimental Traditional Medical Formulae, vol. 21, no. 24, pp. 161–164, 2015. View at Google Scholar
  12. M. Zhang and P. Li, “Experimental study on the effect of Ligustrazine on the expression of apoptosis related genes after cerebral ischemia,” Chinese Traditional Patent Medicine, vol. 25, no. 2, pp. 78–79, 2003. View at Google Scholar
  13. Y. Tian, Y. P. Li, and R. D. Han, “Effects of tetramethylpyrazine on expression of caspase 12 and apoptosis in rats with focal cerebral ischemia and reperfusion,” Journal of Clinical and Experimental Medicine, vol. 13, no. 1, pp. 16–19, 2014. View at Google Scholar
  14. Z. H. Ao, “Observation of curative effect of Ligustrazine Injection in treating acute cerebral infarction,” Journal of Emergency in Traditional Chinese Medicine, vol. 13, no. 6, pp. 351–352, 2004. View at Google Scholar
  15. G. X. Cao, W. Lu, and Q. S. Hu, “Effect of tetramethylpyrazine on 72 cases of cerebral infarction,” Journal of Hubei Institute for Nationalities (Medical Edition), vol. 24, no. 4, pp. 19–21, 2007. View at Google Scholar
  16. Y. M. Che and D. N. Yang, “Clinical analysis of 60 cases of acute cerebral infarction treated with Ligustrazine,” Modern Journal of Integrated Traditional Chinese and Western Medicine, vol. 12, no. 8, p. 823, 2003. View at Google Scholar
  17. Y. L. Gao, L. Li, H. Liu, and F. X. Yang, “Curative effect observation on 36 cases of cerebral infarction treated with Ligustrazine Injection,” Contemporary Medicine, vol. 21, no. 27, pp. 125–126, 2015. View at Google Scholar
  18. L. J. Guo and Z. Y. Yang, “Curative effect observation on 36 cases of cerebral infarction treated with Ligustrazine Injection,” Journal of Community Medicine, vol. 7, no. 14, pp. 24–25, 2009. View at Google Scholar
  19. G. B. Hou, “Ligustrazine injection in the treatment of 70 cases of cerebral infarction,” Guangming Journal of Chinese Medicine, vol. 25, no. 7, p. 1198, 2010. View at Google Scholar
  20. X. J. Huang, “Ligustrazine in the treatment of 56 cases of cerebral infarction,” Shanxi Traditional Chinese Medicine, vol. 29, no. 2, pp. 169–170, 2008. View at Google Scholar
  21. J. H. Li, “Curative effect observation on 60 cases of acute cerebral infarction treated by Ligustrazine,” Chinese Journal of Practical Nervous Diseases, vol. 9, no. 5, pp. 74–75, 2006. View at Google Scholar
  22. S. Y. Lu, “Ligustrazine injection in the treatment of 33 cases of cerebral infarction,” Henan Traditional Chinese Medicine, vol. 33, no. 3, pp. 433–434, 2013. View at Google Scholar
  23. J. Y. Ma, “Ligustrazine in the treatment of 48 cases of acute cerebral infarction,” Zhejiang Practical Medicine, vol. 3, no. 1, p. 41, 1998. View at Google Scholar
  24. L. F. Wan, B. C. Zou, and X. Z. Xu, “Clinical study on the treatment of acute cerebral infarction with ligustrazine injection,” Acta Academiae Medicinae Jiangxi, vol. 43, no. 5, pp. 107–108, 2003. View at Google Scholar
  25. M. X. Tang, “Observation of curative effect of Ligustrazine injection in treating acute cerebral infarction,” Modern Journal of Integrated Traditional Chinese and Western Medicine, vol. 14, no. 18, p. 2419, 2005. View at Google Scholar
  26. Q. F. Wang, “Curative effect observation of 42 cases of acute cerebral thrombosis treated with Ligustrazine injection,” Journal of Practical Medical Techniques, vol. 10, no. 1, p. 29, 2003. View at Google Scholar
  27. J. P. Wu and X. J. Ding, “Clinical observation on 30 cases of acute cerebral infarction treated with Ligustrazine injection,” Journal of Practical Traditional Chinese Internal Medicine, vol. 21, no. 4, pp. 88–90, 2007. View at Google Scholar
  28. C. Xu, “Observation of curative effect of Ligustrazine Injection in treating acute cerebral infarction,” Journal of Qiqihar Medical College, vol. 28, no. 5, pp. 542–543, 2007. View at Google Scholar
  29. X. L. Xu, “Observation of curative effect of Ligustrazine Injection in treating acute cerebral infarction,” Chinese Community Doctors, vol. 9, no. 7, p. 72, 2007. View at Google Scholar
  30. C. R. Xu, P. Guo, and L. M. Liu, “High dose ligustrazine in the treatment of 94 cases of acute cerebral infarction,” Shandong Journal of Traditional Chinese Medicine, vol. 18, no. 9, pp. 396–397, 1999. View at Google Scholar
  31. L. L. Xu, Q. Y. Meng, L. Tian, X. H. Liu, and T. Liu, “Curative effection of tetramethylpyrazine on acute cerebral infarction,” Journal of Practical Traditional Chinese Internal Medicine, vol. 25, no. 9, pp. 57–58, 2011. View at Google Scholar
  32. B. J. Zhou and C. H. Zhao, “Observation of curative effect of ligustrazine in treating acute cerebral infarction,” Chinese Journal of Modern Drug Applications, vol. 3, no. 14, pp. 93–94, 2009. View at Google Scholar
  33. Z. Li, D. S. Zhou, B. B. Wu, and L. Deng, “Advantages and development of traditional Chinese medicine clinical research on cerebral infarction,” Journal of Emergency in Traditional Chinese Medicine, vol. 24, no. 9, pp. 1591–1594, 2015. View at Google Scholar