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Evidence-Based Complementary and Alternative Medicine
Volume 2016, Article ID 3642659, 13 pages
http://dx.doi.org/10.1155/2016/3642659
Review Article

Fever: Views in Anthroposophic Medicine and Their Scientific Validity

1University Children’s Hospital, Tübingen, Germany
2Filderklinik, Filderstadt, Germany

Received 31 August 2016; Accepted 18 October 2016

Academic Editor: Konrad Urech

Copyright © 2016 David D. Martin. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. N. Bertille, E. Purssell, F. Corrard, E. Chiappini, and M. Chalumeau, “Fever phobia 35 years later: did we fail?” Acta Paediatrica, vol. 105, no. 1, pp. 9–10, 2016. View at Publisher · View at Google Scholar · View at Scopus
  2. N. Bertille, E. Fournier-Charrière, G. Pons, and M. Chalumeau, “Managing fever in children: a national survey of parents' knowledge and practices in France,” PLoS ONE, vol. 8, no. 12, Article ID e83469, 2013. View at Publisher · View at Google Scholar · View at Scopus
  3. E. Chiappini, A. Parretti, P. Becherucci et al., “Parental and medical knowledge and management of fever in Italian pre-school children,” BMC Pediatrics, vol. 12, no. 1, article 97, 2012. View at Publisher · View at Google Scholar
  4. E. Purssell, “Treatment of fever and over-the-counter medicines,” Archives of Disease in Childhood, vol. 92, no. 10, pp. 900–901, 2007. View at Publisher · View at Google Scholar · View at Scopus
  5. AnthroMed-Search, http://www.anthromed.de/en/search/.
  6. G. S. Kienle, H.-U. Albonico, E. Baars, H. J. Hamre, P. Zimmermann, and H. Kiene, “Anthroposophic medicine: an integrative medical system originating in Europe,” Global Advances in Health and Medicine, vol. 2, no. 6, pp. 20–31, 2013. View at Publisher · View at Google Scholar
  7. J. S. Alm, J. Swartz, G. Lilja, A. Scheynius, and G. Pershagen, “Atopy in children of families with an anthroposophic lifestyle,” The Lancet, vol. 353, no. 9163, pp. 1485–1488, 1999. View at Publisher · View at Google Scholar · View at Scopus
  8. H. J. Hamre, A. Glockmann, R. Schwarz et al., “Antibiotic use in children with acute respiratory or ear infections: prospective observational comparison of anthroposophic and conventional treatment under routine primary care conditions,” Evidence-Based Complementary and Alternative Medicine, vol. 2014, Article ID 243801, 17 pages, 2014. View at Publisher · View at Google Scholar · View at Scopus
  9. E. Jeschke, C. Lüke, T. Ostermann, M. Tabali, J. Huebner, and H. Matthes, “Verordnungsverhalten anthroposophisch orientierter Ärzte bei akuten Infektionen der oberen Atemwege,” Research in Complementary Medicine, vol. 14, no. 4, pp. 207–215, 2007. View at Google Scholar
  10. Anthroposophy, http://www.goetheanum.org/87.html?&L=1.
  11. R. Steiner and I. Wegman, Fundamentals of Therapy, Rudolf Steiner, Dornach, Switzerland, 1925.
  12. M. Girke, J. Hoppe, P. Matthiessen, and S. Willich, Medizin und Menschenbild. Das Verständnis des Menschen in Schul-und Komplementärmedizin, Deutcher Ärzte, Cologne, Germany, 2006.
  13. A. Husemann and W. Schad, “Zum selbstverständnis der anthroposophischen medizin,” Der Merkurstab, vol. 63, no. 4, pp. 591–592, 2010. View at Google Scholar
  14. M. Glöckler, M. Girke, and H. Matthes, “Anthroposophische Medizin und ihr integratives Paradigma,” in Anthroposophie in Geschichte und Gegenwart, Rahel Uhlenhoff, Berlin, Germany, 2011. View at Google Scholar
  15. A. Büssing, D. Cysarz, F. Edelhäuser, G. Bornhöft, P. F. Matthiessen, and T. Ostermann, “The oil-dispersion bath in anthroposophic medicine—an integrative review,” BMC Complementary and Alternative Medicine, vol. 8, no. 1, article 61, 2008. View at Publisher · View at Google Scholar · View at Scopus
  16. A. Büssing, T. Ostermann, M. Majorek, and P. F. Matthiessen, “Eurythmy therapy in clinical studies: a systematic literature review,” BMC Complementary and Alternative Medicine, vol. 8, no. 1, article 8, 2008. View at Publisher · View at Google Scholar · View at Scopus
  17. H. J. Hamre, C. M. Witt, A. Glockmann, R. Ziegler, S. N. Willich, and H. Kiene, “Eurythmy therapy in chronic disease: a four-year prospective cohort study,” BMC Public Health, vol. 7, no. 1, article 61, 2007. View at Publisher · View at Google Scholar · View at Scopus
  18. G. S. Kienle, H. Kiene, and H. U. Albonico, Anthroposophic Medicine: Effectiveness, Utility, Costs, Safety, Schattauer, Stuttgart, Germany, 2006.
  19. G. Soldner and H. M. Stellman, Individual Paediatrics: Physical, Emotional and Spiritual Aspects of Diagnosis and Counseling—Anthroposophic-homeopathic Therapy, CRC Press, New York, NY, USA, 4th edition, 2014.
  20. M. Girke, Grundlagen und Therapeutische Konzepte der Anthroposophischen, Salumed, Berlin, Germany, 2nd edition, 2012.
  21. J. Vagedes and G. Soldner, Das Kinder-Gesundheitsbuch, Graefe Und Unzer, München, Germany, 2008.
  22. M. Glöckler and W. Goebel, A Guide to Child Health: A Holistic Approach to Raising Healthy Children, Floris Books, Edinburgh, UK, 2013.
  23. K. R. Kummer, “1001mal Masern-prospektive Untersuchung von 886 und retrospektive von 115 Verläufen in der Praxis,” Der Merkurstab, vol. 52, pp. 369–375, 1999. View at Publisher · View at Google Scholar
  24. T. von Schoen-Angerer, J. Wilkens, G. S. Kienle, H. Kiene, and J. Vagedes, “High-dose viscum album extract treatment in the prevention of recurrent bladder cancer: a retrospective case series,” The Permanente Journal, vol. 19, no. 4, pp. 76–83, 2015. View at Publisher · View at Google Scholar
  25. F. Huseman, “Scharlach und eitrige Angina in zehn Jahren Praxis,” Der Merkurstab, vol. 51, no. 1, pp. 16–24, 1998. View at Google Scholar
  26. G. Soldner and H. M. Stellman, “Krankheitsbekämpfung und gesundheitsentwicklung: therapiemöglichkeiten der pneumonie im kindesalter,” Der Merkurstab, vol. 55, pp. 43–49, 2002. View at Google Scholar
  27. I. A. Harmsen, R. A. C. Ruiter, T. G. W. Paulussen, L. Mollema, G. Kok, and H. E. de Melker, “Factors that influence vaccination decision-making by parents who visit an anthroposophical child welfare center: a focus group study,” Advances in Preventive Medicine, vol. 2012, Article ID 175694, 7 pages, 2012. View at Publisher · View at Google Scholar
  28. V. Fintelmann, M. Hopferwieser, B. Kennyeres, and S. Görnitz, “Die Masernepidemie in Salzburg, Ostern 2008,” Der Merkurstab, vol. 64, pp. 128–142, 2011. View at Publisher · View at Google Scholar
  29. P. Busche, “Measles in Adulthood—a case report,” Der Merkurstab, vol. 68, no. 6, pp. 455–458, 2015. View at Google Scholar
  30. H. U. Albonico, H. U. Bräker, and J. Hüsler, “Febrile infectious childhood diseases in the history of cancer patients and matched controls,” Medical Hypotheses, vol. 51, no. 4, pp. 315–320, 1998. View at Publisher · View at Google Scholar · View at Scopus
  31. O. Zerbo, A.-M. Iosif, C. Walker, S. Ozonoff, R. L. Hansen, and I. Hertz-Picciotto, “Is maternal influenza or fever during pregnancy associated with autism or developmental delays? Results from the CHARGE (childhood Autism Risks from Genetics and Environment) study,” Journal of Autism and Developmental Disorders, vol. 43, no. 1, pp. 25–33, 2013. View at Publisher · View at Google Scholar · View at Scopus
  32. A. Mouihate, E.-M. Harré, S. Martin, and Q. J. Pittman, “Suppression of the febrile response in late gestation: evidence, mechanisms and outcomes,” Journal of Neuroendocrinology, vol. 20, no. 4, pp. 508–514, 2008. View at Publisher · View at Google Scholar · View at Scopus
  33. P. Rice, E. Martin, J.-R. He et al., “Febrile-range hyperthermia augments neutrophil accumulation and enhances lung injury in experimental gram-negative bacterial pneumonia,” The Journal of Immunology, vol. 174, no. 6, pp. 3676–3685, 2005. View at Publisher · View at Google Scholar · View at Scopus
  34. E. Liu, K. Lewis, H. Al-Saffar et al., “Naturally occurring hypothermia is more advantageous than fever in severe forms of lipopolysaccharide- and Escherichia coli-induced systemic inflammation,” American Journal of Physiology—Regulatory Integrative and Comparative Physiology, vol. 302, no. 12, pp. R1372–R1383, 2012. View at Publisher · View at Google Scholar · View at Scopus
  35. J. D. Hasday, A. Garrison, I. S. Singh et al., “Febrile-range hyperthermia augments pulmonary neutrophil recruitment and amplifies pulmonary oxygen toxicity,” American Journal of Pathology, vol. 162, no. 6, pp. 2005–2017, 2003. View at Publisher · View at Google Scholar · View at Scopus
  36. S.-B. Hong, Y. Koh, I.-C. Lee et al., “Induced hypothermia as a new approach to lung rest for the acutely injured lung,” Critical Care Medicine, vol. 33, no. 9, pp. 2049–2055, 2005. View at Publisher · View at Google Scholar · View at Scopus
  37. Y. Ghandi, P. Yousefi Chaichi, M. Sharifi, and N. Bolandnazar, “The brugada syndrome unmasked by fever in a two-year-old child: case report,” Journal of Comprehensive Pediatrics, vol. 7, article 1, 2016. View at Publisher · View at Google Scholar
  38. V. Probst, I. Denjoy, P. G. Meregalli et al., “Clinical aspects and prognosis of Brugada syndrome in children,” Circulation, vol. 115, no. 15, pp. 2042–2048, 2007. View at Publisher · View at Google Scholar · View at Scopus
  39. F. Schortgen, K. Clabault, S. Katsahian et al., “Fever control using external cooling in septic shock: a randomized controlled trial,” American Journal of Respiratory and Critical Care Medicine, vol. 185, no. 10, pp. 1088–1095, 2012. View at Publisher · View at Google Scholar · View at Scopus
  40. N. Shime, K. Hosokawa, and G. MacLaren, “Does cooling really improve outcomes in patients with septic shock?” American Journal of Respiratory and Critical Care Medicine, vol. 187, no. 11, pp. 1274–1275, 2013. View at Publisher · View at Google Scholar · View at Scopus
  41. M. J. Mina, C. J. E. Metcalf, R. L. de Swart, A. D. M. E. Osterhaus, and B. T. Grenfell, “Long-term measles-induced immunomodulation increases overall childhood infectious disease mortality,” Science, vol. 348, no. 6235, pp. 694–699, 2015. View at Publisher · View at Google Scholar · View at Scopus
  42. L. M. Harden, S. Kent, Q. J. Pittman, and J. Roth, “Fever and sickness behavior: friend or foe?” Brain, Behavior, and Immunity, vol. 50, pp. 322–333, 2015. View at Publisher · View at Google Scholar · View at Scopus
  43. L. E. Williams and J. A. Bargh, “Experiencing physical warmth promotes interpersonal warmth,” Science, vol. 322, no. 5901, pp. 606–607, 2008. View at Publisher · View at Google Scholar · View at Scopus
  44. Y. Kang, L. E. Williams, M. S. Clark, J. R. Gray, and J. A. Bargh, “Physical temperature effects on trust behavior: the role of insula,” Social Cognitive and Affective Neuroscience, vol. 6, no. 4, pp. 507–515, 2011. View at Publisher · View at Google Scholar · View at Scopus
  45. P. A. Mackowiak, “Concepts of fever,” Archives of Internal Medicine, vol. 158, no. 17, pp. 1870–1881, 1998. View at Publisher · View at Google Scholar · View at Scopus
  46. M. J. Kluger, “Phylogeny of fever,” Federation Proceedings, vol. 38, no. 1, pp. 30–34, 1979. View at Google Scholar
  47. C. M. Blatteis, “Fever: is it beneficial?” Yale Journal of Biology and Medicine, vol. 59, no. 2, pp. 107–116, 1986. View at Google Scholar · View at Scopus
  48. H. A. Bernheim and M. J. Kluger, “Fever: effect of drug-induced antipyresis on survival,” Science, vol. 193, no. 4249, pp. 237–239, 1976. View at Publisher · View at Google Scholar · View at Scopus
  49. S. Eyers, M. Weatherall, P. Shirtcliffe, K. Perrin, and R. Beasley, “The effect on mortality of antipyretics in the treatment of influenza infection: systematic review and meta-analyis,” Journal of the Royal Society of Medicine, vol. 103, no. 10, pp. 403–411, 2010. View at Publisher · View at Google Scholar · View at Scopus
  50. T. F. Doran, C. D. Angelis, R. A. Baumgardner, and E. D. Mellits, “Acetaminophen: more harm than good for chickenpox?” The Journal of Pediatrics, vol. 114, no. 6, pp. 1045–1048, 1989. View at Publisher · View at Google Scholar · View at Scopus
  51. C. H. Brandts, M. Ndjavé, W. Graninger, and P. G. Kremsner, “Effect of paracetamol on parasite clearance time in Plasmodium falciparum malaria,” The Lancet, vol. 350, no. 9079, pp. 704–709, 1997. View at Publisher · View at Google Scholar · View at Scopus
  52. C. I. Schulman, N. Namias, J. Doherty et al., “The effect of antipyretic therapy upon outcomes in critically ill patients: A Randomized, Prospective Study,” Surgical Infections, vol. 6, no. 4, pp. 369–375, 2005. View at Publisher · View at Google Scholar · View at Scopus
  53. P. A. Mackowiak, “Direct effects of hyperthermia on pathogenic microorganisms: teleologic implications with regard to fever,” Reviews of Infectious Diseases, vol. 3, no. 3, pp. 508–520, 1981. View at Publisher · View at Google Scholar · View at Scopus
  54. P. A. Mackowiak and M. Marling-Cason, “Hyperthermic enhancement of serum antimicrobial activity: mechanism by which fever might exert a beneficial effect on the outcome of gram-negative sepsis,” Infection and Immunity, vol. 39, no. 1, pp. 38–42, 1983. View at Google Scholar · View at Scopus
  55. M. M. Appenheimer, Q. Chen, R. A. Girard, W.-C. Wang, and S. S. Evans, “Impact of fever-range thermal stress on lymphocyte-endothelial adhesion and lymphocyte trafficking,” Immunological Investigations, vol. 34, no. 3, pp. 295–323, 2005. View at Publisher · View at Google Scholar · View at Scopus
  56. N. J. Roberts Jr., “Temperature and host defense,” Microbiological Reviews, vol. 43, no. 2, pp. 241–259, 1979. View at Google Scholar · View at Scopus
  57. K. I. Plaisance, S. Kudaravalli, S. S. Wasserman, M. M. Levine, and P. A. Mackowiak, “Effect of antipyretic therapy on the duration of illness in experimental influenza A, Shigella sonnei, and Rickettsia rickettsii infections,” Pharmacotherapy, vol. 20, no. 12, pp. 1417–1422, 2000. View at Publisher · View at Google Scholar · View at Scopus
  58. R. E. Bryant, A. F. Hood, C. E. Hood, and M. G. Koenig, “Factors affecting mortality of gram-negative rod bacteremia,” Archives of Internal Medicine, vol. 127, no. 1, pp. 120–128, 1971. View at Publisher · View at Google Scholar · View at Scopus
  59. S. Ahkee, L. Srinath, and J. Ramirez, “Community-acquired pneumonia in the elderly: association of mortality with lack of fever and leukocytosis,” Southern Medical Journal, vol. 90, no. 3, pp. 296–298, 1997. View at Publisher · View at Google Scholar · View at Scopus
  60. L. P. Sutton and K. G. Dodge, “The treatment of chorea by induced fever,” The Journal of Pediatrics, vol. 3, no. 6, pp. 813–826, 1933. View at Publisher · View at Google Scholar · View at Scopus
  61. L. P. Sutton and K. G. Dodge, “Fever therapy in chorea and in rheumatic carditis with and without chorea,” The Journal of Laboratory and Clinical Medicine, vol. 21, no. 6, pp. 619–628, 1936. View at Google Scholar · View at Scopus
  62. S. Baize, P. Marianneau, P. Loth et al., “Early and strong immune responses are associated with control of viral replication and recovery in Lassa virus-infected cynomolgus monkeys,” Journal of Virology, vol. 83, no. 11, pp. 5890–5903, 2009. View at Publisher · View at Google Scholar · View at Scopus
  63. S. V. Baudouin, D. Saunders, W. Tiangyou et al., “Mitochondrial DNA and survival after sepsis: a prospective study,” The Lancet, vol. 366, no. 9503, pp. 2118–2121, 2005. View at Publisher · View at Google Scholar · View at Scopus
  64. R. Hanada, A. Leibbrandt, T. Hanada et al., “Central control of fever and female body temperature by RANKL/RANK,” Nature, vol. 462, no. 7272, pp. 505–509, 2009. View at Publisher · View at Google Scholar · View at Scopus
  65. P. Young, M. Saxena, R. Bellomo et al., “Acetaminophen for fever in critically ill patients with suspected infection,” The New England Journal of Medicine, vol. 373, no. 23, pp. 2215–2224, 2015. View at Publisher · View at Google Scholar · View at Scopus
  66. R. Prymula, C.-A. Siegrist, R. Chlibek et al., “Effect of prophylactic paracetamol administration at time of vaccination on febrile reactions and antibody responses in children: two open-label, randomised controlled trials,” The Lancet, vol. 374, no. 9698, pp. 1339–1350, 2009. View at Publisher · View at Google Scholar · View at Scopus
  67. M. Richardson and E. Purssell, “Who's afraid of fever?” Archives of Disease in Childhood, vol. 100, no. 9, pp. 818–820, 2015. View at Publisher · View at Google Scholar · View at Scopus
  68. A. Beyerlein, F. Wehweck, A.-G. Ziegler, and M. Pflueger, “Respiratory infections in early life and the development of islet autoimmunity in children at increased type 1 diabetes risk: evidence from the BABYDIET study,” JAMA Pediatrics, vol. 167, no. 9, pp. 800–807, 2013. View at Publisher · View at Google Scholar · View at Scopus
  69. R. Beasley, T. Clayton, J. Crane et al., “Association between paracetamol use in infancy and childhood, and risk of asthma, rhinoconjunctivitis, and eczema in children aged 6-7 years: analysis from Phase Three of the ISAAC programme,” The Lancet, vol. 372, no. 9643, pp. 1039–1048, 2008. View at Publisher · View at Google Scholar · View at Scopus
  70. M. Etminan, M. Sadatsafavi, S. Jafari, M. Doyle-Waters, K. Aminzadeh, and J. M. FitzGerald, “Acetaminophen use and the risk of asthma in children and adults: a systematic review and metaanalysis,” Chest, vol. 136, no. 5, pp. 1316–1323, 2009. View at Publisher · View at Google Scholar · View at Scopus
  71. M. S. Perzanowski, R. L. Miller, D. Tang et al., “Prenatal acetaminophen exposure and risk of wheeze at age 5 years in an urban low-income cohort,” Thorax, vol. 65, no. 2, pp. 118–123, 2010. View at Publisher · View at Google Scholar · View at Scopus
  72. D. Kanabar, S. Dale, and M. Rawat, “A review of ibuprofen and acetaminophen use in febrile children and the occurrence of asthma-related symptoms,” Clinical Therapeutics, vol. 29, no. 12, pp. 2716–2723, 2007. View at Publisher · View at Google Scholar · View at Scopus
  73. L. K. Williams, E. L. Peterson, D. R. Ownby, and C. C. Johnson, “The relationship between early fever and allergic sensitization at age 6 to 7 years,” Journal of Allergy and Clinical Immunology, vol. 113, no. 2, pp. 291–296, 2004. View at Publisher · View at Google Scholar · View at Scopus
  74. L. K. Williams, E. L. Peterson, M. Pladevall, K. Tunceli, D. R. Ownby, and C. C. Johnson, “Timing and intensity of early fevers and the development of allergies and asthma,” Journal of Allergy and Clinical Immunology, vol. 116, no. 1, pp. 102–108, 2005. View at Publisher · View at Google Scholar · View at Scopus
  75. E. von Mutius, S. Illi, T. Hirsch, W. Leupold, U. Keil, and S. K. Weiland, “Frequency of infections and risk of asthma, atopy and airway hyperresponsiveness in children,” European Respiratory Journal, vol. 14, no. 1, pp. 4–11, 1999. View at Publisher · View at Google Scholar · View at Scopus
  76. K.-M. Ahn, M.-S. Lee, S.-J. Hong et al., “Fever, use of antibiotics, and acute gastroenteritis during infancy as risk factors for the development of asthma in Korean school-age children,” Journal of Asthma, vol. 42, no. 9, pp. 745–750, 2005. View at Publisher · View at Google Scholar · View at Scopus
  77. P. M. Matricardi, F. Franzinelli, A. Franco et al., “Sibship size, birth order, and atopy in 11,371 Italian young men,” Journal of Allergy and Clinical Immunology, vol. 101, no. 4, pp. 439–444, 1998. View at Publisher · View at Google Scholar · View at Scopus
  78. L. K. Curran, C. J. Newschaffer, L.-C. Lee, S. O. Crawford, M. V. Johnston, and A. W. Zimmerman, “Behaviors associated with fever in children with autism spectrum disorders,” Pediatrics, vol. 120, no. 6, pp. e1386–e1392, 2007. View at Publisher · View at Google Scholar · View at Scopus
  79. M. F. Mehler and D. P. Purpura, “Autism, fever, epigenetics and the locus coeruleus,” Brain Research Reviews, vol. 59, no. 2, pp. 388–392, 2009. View at Publisher · View at Google Scholar · View at Scopus
  80. D. Mischkowski, J. Crocker, and B. M. Way, “From painkiller to empathy killer: acetaminophen (paracetamol) reduces empathy for pain,” Social Cognitive and Affective Neuroscience, vol. 11, no. 9, pp. 1345–1353, 2016. View at Publisher · View at Google Scholar
  81. W. Schad, Goethes Weltkultur, Freies Geistesleben, Stuttgart, Germany, 2007.
  82. J. D. F. Jones, Teller of Many Tales: The Lives of Laurens van der Post, Carroll & Graf; 1st Carroll & Graf Ed edition, New York, NY, USA, 2002.
  83. J. W. Rohen and A. Landman-Reiner, “Functional morphology, the dynamic wholeness of the human organism,” The Journal of Alternative and Complementary Medicine, vol. 14, no. 7, pp. 855–856, 2008. View at Publisher · View at Google Scholar
  84. W. L. Kenney and T. A. Munce, “Aging and human temperature regulation,” Journal of Applied Physiology, vol. 95, no. 6, pp. 2598–2603, 2003. View at Publisher · View at Google Scholar · View at Scopus
  85. M.-C. Roghmann, J. Warner, and P. A. Mackowiak, “The relationship between age and fever magnitude,” American Journal of the Medical Sciences, vol. 322, no. 2, pp. 68–70, 2001. View at Publisher · View at Google Scholar · View at Scopus
  86. L. M. Coussens and Z. Werb, “Inflammation and cancer,” Nature, vol. 420, no. 6917, pp. 860–867, 2002. View at Publisher · View at Google Scholar · View at Scopus
  87. R. Grossarth-Maticek, R. Frentzel-Beyme, D. Kanazir, M. Jankovic, and H. Vetter, “Reported herpes-virus-infection, fever and cancer incidence in a prospective study,” Journal of Chronic Diseases, vol. 40, no. 10, pp. 967–976, 1987. View at Publisher · View at Google Scholar · View at Scopus
  88. S. Wrotek, K. Kamecki, S. Kwiatkowski, and W. Kozak, “Cancer patients report a history of fewer fevers during infections than healthy controls,” Journal of Pre-Clinical and Clinical Research, vol. 3, no. 1, pp. 031–035, 2009. View at Google Scholar
  89. K. F. Kölmel, A. Pfahlberg, G. Mastrangelo et al., “Infections and melanoma risk: results of a multicentre EORTC case- control study,” Melanoma Research, vol. 9, no. 5, pp. 511–519, 1999. View at Publisher · View at Google Scholar · View at Scopus
  90. B. Krone, K. Kölmel, J. Grange et al., “Impact of vaccinations and infectious diseases on the risk of melanoma—evaluation of an EORTC case-control study,” European Journal of Cancer, vol. 39, no. 16, pp. 2372–2378, 2003. View at Google Scholar
  91. G. Kienle and H. Kiene, “From reductionism to holism: systems-oriented approaches in cancer research,” Global Advances in Health and Medicine, vol. 1, no. 5, pp. 68–77, 2012. View at Publisher · View at Google Scholar
  92. K. M. Kokolus, M. L. Capitano, C.-T. Lee et al., “Baseline tumor growth and immune control in laboratory mice are significantly influenced by subthermoneutral housing temperature,” Proceedings of the National Academy of Sciences of the United States of America, vol. 110, no. 50, pp. 20176–20181, 2013. View at Publisher · View at Google Scholar · View at Scopus
  93. J. R. Ostberg and E. A. Repasky, “Emerging evidence indicates that physiologically relevant thermal stress regulates dendritic cell function,” Cancer Immunology, Immunotherapy, vol. 55, no. 3, pp. 292–298, 2006. View at Publisher · View at Google Scholar · View at Scopus
  94. D. F. Hanson, “Fever, temperature, and the immune response,” Annals of the New York Academy of Sciences, vol. 813, pp. 453–464, 1997. View at Publisher · View at Google Scholar · View at Scopus
  95. C. M. Blatteis, “Endotoxic fever: new concepts of its regulation suggest new approaches to its management,” Pharmacology & Therapeutics, vol. 111, no. 1, pp. 194–223, 2006. View at Publisher · View at Google Scholar · View at Scopus
  96. S. Hajdu, J. Holinka, S. Reichmann, A. M. Hirschl, W. Graninger, and E. Presterl, “Increased temperature enhances the antimicrobial effects of daptomycin, vancomycin, tigecycline, fosfomycin, and cefamandole on staphylococcal biofilms,” Antimicrobial Agents and Chemotherapy, vol. 54, no. 10, pp. 4078–4084, 2010. View at Publisher · View at Google Scholar · View at Scopus
  97. W. B. Coley, “The treatment of sarcoma of the long bones,” Annals of Surgery, vol. 97, no. 3, pp. 434–460, 1933. View at Publisher · View at Google Scholar
  98. G. S. Kienle, “Fever in cancer treatment: Coley's therapy and epidemiologic observations,” Global Advances in Health and Medicine, vol. 1, no. 1, pp. 92–100, 2012. View at Publisher · View at Google Scholar
  99. U. Hobohm, “Fever and cancer in perspective,” Cancer Immunology, Immunotherapy, vol. 50, no. 8, pp. 391–396, 2001. View at Google Scholar · View at Scopus
  100. R. Kleef, W. B. Jonas, W. Knogler, and W. Stenzinger, “Fever, cancer incidence and spontaneous remissions,” NeuroImmunoModulation, vol. 9, no. 2, pp. 55–64, 2001. View at Publisher · View at Google Scholar · View at Scopus
  101. U. Hobohm, “Fever therapy revisited,” British Journal of Cancer, vol. 92, no. 3, pp. 421–425, 2005. View at Publisher · View at Google Scholar · View at Scopus
  102. B. O'Regan and C. Hirshberg, Spontaneous Remission: An Annotated Bibliography, Institute of Noetic Sciences, Sausalito, Calif, USA, 1995.
  103. R. Kleef and E. D. Hager, “Fever, pyrogens and cancer,” in Hyperthermia in Cancer Treatment: A Primer, G. Baronzio and E. D. Hager, Eds., pp. 680–710, Springer, New York, NY, USA, 2006. View at Google Scholar
  104. A. S. Abdelrazeq, “Spontaneous regression of colorectal cancer: a review of cases from 1900 to 2005,” International Journal of Colorectal Disease, vol. 22, no. 7, pp. 727–736, 2007. View at Publisher · View at Google Scholar · View at Scopus
  105. R. Madeleyn, G. Soldner, C. Tautz, and B. von Laue, “Hirntumore bei kindern: therapieverläufe/Teil II,” Der Merkurstab, vol. 1, pp. 36–47, 2002. View at Google Scholar
  106. S. A. Hoption Cann, J. P. Van Netten, C. Van Netten, and D. W. Glover, “Spontaneous regression: a hidden treasure buried in time,” Medical Hypotheses, vol. 58, no. 2, pp. 115–119, 2002. View at Publisher · View at Google Scholar · View at Scopus
  107. Y. Takeda, H. Togashi, H. Shinzawa et al., “Spontaneous regression of hepatocellular carcinoma and review of literature,” Journal of Gastroenterology and Hepatology, vol. 15, no. 9, pp. 1079–1086, 2000. View at Publisher · View at Google Scholar · View at Scopus
  108. R. Steiner, Spiritual Science and Medicine, Rudolf Steiner, Dornach, Switzerland, 7th edition, 1999.
  109. M. Orange, Mistletoe therapy for cancer patients. Thesis for the degree of master of science in clinical oncology [M.S. thesis], The University of Birmingham, Birmingham, UK, 2011, http://www.anthromed.org/UploadedDocuments/0_Dissertation_compressed.pdf.
  110. V. P. Chernyshov, P. Heusser, L. I. Omelchenko et al., “Immunomodulatory and clinical effects of Viscum album (Iscador M and Iscador P) in children with recurrent respiratory infections as a result of the chernobyl nuclear accident,” American Journal of Therapeutics, vol. 7, no. 3, pp. 195–203, 2000. View at Publisher · View at Google Scholar · View at Scopus
  111. J. Melzer, F. Iten, K. Hostanska, and R. Saller, “Efficacy and safety of mistletoe preparations (Viscum album) for patients with cancer diseases,” Forsch Komplementmed, vol. 16, no. 4, pp. 217–226, 2009. View at Publisher · View at Google Scholar
  112. M. Orange, A. Lace, M. P. Fonseca, B. H. von Laue, S. Geider, and G. S. Kienle, “Durable regression of primary cutaneous b-cell lymphoma following fever-inducing mistletoe treatment: two case reports,” Global Advances in Health and Medicine, vol. 1, no. 1, pp. 18–25, 2012. View at Publisher · View at Google Scholar
  113. F. Schad, J. Atxner, D. Buchwald et al., “Intratumoral mistletoe (Viscum album L) therapy in patients with unresectable pancreas carcinoma: a retrospective analysis,” Integrative Cancer Therapies, vol. 13, no. 4, pp. 332–340, 2014. View at Publisher · View at Google Scholar · View at Scopus
  114. M. Mabed, L. El-Helw, and S. Shamaa, “Phase II study of viscum fraxini-2 in patients with advanced hepatocellular carcinoma,” British Journal of Cancer, vol. 90, no. 1, pp. 65–69, 2004. View at Publisher · View at Google Scholar · View at Scopus
  115. M. Orange, U. Reuter, and U. Hobohm, “Coley's lessons remembered: augmenting mistletoe therapy,” Integrative Cancer Therapies, 2016. View at Publisher · View at Google Scholar
  116. R. Penter, “The time of injection and the full course of a cycle of endogenous hyperthermia during the first treatment with mistletoe,” Der Merkurstab, vol. 64, pp. 20–39, 2011. View at Google Scholar
  117. H. B. von Laue and M. Frühwirth, “Viscum-Therapie und Tumorfieber—zwei Fallbeispiele mit langfristig gutem Verlauf,” in Die Mistel in der Tumortherapie: Grundlagenforschung und Klinik, KVC, 2001. View at Google Scholar
  118. V. F. Semiglazov, V. V. Stepula, A. Dudov, J. Schnitker, and U. Mengs, “Quality of life is improved in breast cancer patients by standardised mistletoe extract PS76A2 during chemotherapy and follow-up: a randomised, placebo-controlled, double-blind, multicentre clinical trial,” Anticancer Research, vol. 26, no. 2, pp. 1519–1529, 2006. View at Google Scholar · View at Scopus
  119. G. S. Kienle and H. Kiene, “Influence of Viscum album L (European Mistletoe) extracts on quality of life in cancer patients: a systematic review of controlled clinical studies,” Integrative Cancer Therapies, vol. 9, no. 2, pp. 142–157, 2010. View at Publisher · View at Google Scholar · View at Scopus
  120. W. Tröger, D. Galun, M. Reif, A. Schumann, N. Stanković, and M. Milićević, “Quality of life of patients with advanced pancreatic cancer during treatment with mistletoe,” Deutsches Arzteblatt International, vol. 111, no. 29-30, pp. 493–502, 2014. View at Google Scholar
  121. J. Maldacker, “Preclinical investigations with mistletoe (Viscum album L.) extract Iscador,” Arzneimittel-Forschung, vol. 56, no. 6, pp. 497–507, 2006. View at Google Scholar · View at Scopus
  122. W. Tröger, D. Galun, M. Reif, A. Schumann, N. Stanković, and M. Milićević, “Viscum album [L.] extract therapy in patients with locally advanced or metastatic pancreatic cancer: a randomised clinical trial on overall survival,” European Journal of Cancer, vol. 49, no. 18, pp. 3788–3797, 2013. View at Publisher · View at Google Scholar · View at Scopus
  123. A. Longhi, M. Reif, E. Mariani, and S. Ferrari, “A randomized study on postrelapse disease-free survival with adjuvant mistletoe versus oral etoposide in osteosarcoma patients,” Evidence-Based Complementary and Alternative Medicine, vol. 2014, Article ID 210198, 9 pages, 2014. View at Publisher · View at Google Scholar · View at Scopus
  124. A. S. M. El-Radhi, “Why is the evidence not affecting the practice of fever management?” Archives of Disease in Childhood, vol. 93, no. 11, pp. 918–920, 2008. View at Publisher · View at Google Scholar · View at Scopus
  125. J. E. Sullivan and H. C. Farrar, “Clinical report—fever and antipyretic use in children,” Pediatrics, vol. 108, no. 4, p. 1020, 2011. View at Google Scholar
  126. E. R. Southey, K. Soares-Weiser, and J. Kleijnen, “Systematic review and meta-analysis of the clinical safety and tolerability of ibuprofen compared with paracetamol in paediatric pain and fever,” Current Medical Research and Opinion, vol. 25, no. 9, pp. 2207–2222, 2009. View at Publisher · View at Google Scholar · View at Scopus
  127. C. Souyri, P. Olivier, S. Grolleau, and M. Lapeyre-Mestre, “Severe necrotizing soft-tissue infections and nonsteroidal anti-inflammatory drugs,” Clinical and Experimental Dermatology, vol. 33, no. 3, pp. 249–255, 2008. View at Publisher · View at Google Scholar · View at Scopus
  128. L. M. Ford and J. Waksman, “Necrotizing fasciitis during primary varicella,” Pediatrics, vol. 105, no. 6, pp. 1372–1375, 2000. View at Publisher · View at Google Scholar · View at Scopus
  129. R. P. Veenstra, W. E. Manson, T. S. van der Werf et al., “Fulminant necrotizing fasciitis and nonsteroidal antiinflammatory drugs,” Intensive Care Medicine, vol. 27, no. 11, p. 1831, 2001. View at Publisher · View at Google Scholar · View at Scopus
  130. A. Hidalgo-Carballal and M. P. Suárez-Mier, “Sudden unexpected death in a child with varicella caused by necrotizing fasciitis and streptococcal toxic shock syndrome,” The American Journal of Forensic Medicine and Pathology, vol. 27, no. 1, pp. 93–96, 2006. View at Publisher · View at Google Scholar · View at Scopus
  131. T.-C. Weng, C.-C. Chen, H.-S. Toh, and H.-J. Tang, “Ibuprofen worsens Streptococcus pyogenes soft tissue infections in mice,” Journal of Microbiology, Immunology and Infection, vol. 44, no. 6, pp. 418–423, 2011. View at Publisher · View at Google Scholar · View at Scopus
  132. C. L. Byington, L. Y. Spencer, T. A. Johnson et al., “An epidemiological investigation of a sustained high rate of pediatric parapneumonic empyema: risk factors and microbiological associations,” Clinical Infectious Diseases, vol. 34, no. 4, pp. 434–440, 2002. View at Publisher · View at Google Scholar · View at Scopus
  133. P. François, A. Desrumaux, C. Cans, I. Pin, P. Pavese, and J. Labarère, “Prevalence and risk factors of suppurative complications in children with pneumonia,” Acta Paediatrica, vol. 99, no. 6, pp. 861–866, 2010. View at Publisher · View at Google Scholar · View at Scopus
  134. M. A. Elemraid, M. F. Thomas, A. P. Blain et al., “Risk factors for the development of pleural empyema in children,” Pediatric Pulmonology, vol. 50, no. 7, pp. 721–726, 2015. View at Publisher · View at Google Scholar · View at Scopus
  135. M. Le Bourgeois, A. Ferroni, M. Leruez-Ville et al., “Nonsteroidal anti-inflammatory drug without antibiotics for acute viral infection increases the empyema risk in children: a matched case-control study,” The Journal of Pediatrics, vol. 175, pp. 47–53.e3, 2016. View at Publisher · View at Google Scholar
  136. G. Voiriot, S. Dury, A. Parrot, C. Mayaud, and M. Fartoukh, “Nonsteroidal antiinflammatory drugs may affect the presentation and course of community-acquired pneumonia,” Chest, vol. 139, no. 2, pp. 387–394, 2011. View at Publisher · View at Google Scholar · View at Scopus
  137. Y. Mikaeloff, A. Kezouh, and S. Suissa, “Nonsteroidal anti-inflammatory drug use and the risk of severe skin and soft tissue complications in patients with varicella or zoster disease,” British Journal of Clinical Pharmacology, vol. 65, no. 2, pp. 203–209, 2008. View at Publisher · View at Google Scholar · View at Scopus
  138. J. F. Ludvigsson, “Epidemiological study of constipation and other gastrointestinal symptoms in 8000 children,” Acta Paediatrica, vol. 95, no. 5, pp. 573–580, 2006. View at Publisher · View at Google Scholar · View at Scopus
  139. S. M. Lesko and A. A. Mitchell, “An assessment of the safety of pediatric ibuprofen: a practitioner-based randomized clinical trial,” The Journal of the American Medical Association, vol. 273, no. 12, pp. 929–933, 1995. View at Publisher · View at Google Scholar · View at Scopus
  140. P. Nourjah, S. R. Ahmad, C. Karwoski, and M. Willy, “Estimates of acetaminophen (paracetomal)-associated overdoses in the United States,” Pharmacoepidemiology and Drug Safety, vol. 15, no. 6, pp. 398–405, 2006. View at Publisher · View at Google Scholar · View at Scopus
  141. L. W. Kang, M. I. Kidon, C. W. Chin, L. S. Hoon, C. Y. Hwee, and N. K. Chong, “Severe anaphylactic reaction to ibuprofen in a child with recurrent urticaria,” Pediatrics, vol. 120, no. 3, pp. e742–e744, 2007. View at Publisher · View at Google Scholar · View at Scopus
  142. C. Bachmeyer, C. Vermeulen, R. Habki, F. Blay, and F. Leynadier, “Acetaminophen (paracetamol)-induced anaphylactic shock,” Southern Medical Journal, vol. 95, no. 7, pp. 759–761, 2002. View at Publisher · View at Google Scholar · View at Scopus
  143. S. S. Jain, S. Green, and M. Rose, “Anaphylaxis following intravenous paracetamol: the problem is the solution,” Anaesthesia and Intensive Care, vol. 43, no. 6, pp. 779–781, 2015. View at Google Scholar
  144. N. M. H. Graham, C. J. Burrell, R. M. Douglas, P. Debelle, and L. Davies, “Adverse effects of aspirin, acetaminophen, and ibuprofen on immune function, viral shedding, and clinical status in rhinovirus-infected volunteers,” Journal of Infectious Diseases, vol. 162, no. 6, pp. 1277–1282, 1990. View at Publisher · View at Google Scholar · View at Scopus
  145. R. H. Husseini, C. Sweet, M. H. Collie, and H. Smith, “Elevation of nasal viral levels by suppression of fever in ferrets infected with influenza viruses of differing virulence,” Journal of Infectious Diseases, vol. 145, no. 4, pp. 520–524, 1982. View at Publisher · View at Google Scholar · View at Scopus
  146. D. J. Earn, P. W. Andrews, and B. M. Bolker, “Population-level effects of suppressing fever,” Proceedings of the Royal Society of London B: Biological Sciences, vol. 281, no. 1778, 2014. View at Google Scholar
  147. M. S. Kramer, L. E. Naimark, R. Roberts-Bräuer, A. McDougall, and D. G. Leduc, “Risks and benefits of paracetamol antipyresis in young children with fever of presumed viral origin,” The Lancet, vol. 337, no. 8741, pp. 591–594, 1991. View at Publisher · View at Google Scholar · View at Scopus
  148. A. S. El-Radhi, “Lower degree of fever at the initial febrile convulsion is associated with increased risk of subsequent convulsions,” European Journal of Paediatric Neurology, vol. 2, no. 2, pp. 91–96, 1998. View at Publisher · View at Google Scholar · View at Scopus
  149. T. Strengell, M. Uhari, R. Tarkka et al., “Antipyretic agents for preventing recurrences of febrile seizures: randomized controlled trial,” Archives of Pediatrics and Adolescent Medicine, vol. 163, no. 9, pp. 799–804, 2009. View at Publisher · View at Google Scholar · View at Scopus
  150. M. Offringa and R. Newton, “Prophylactic drug management for febrile seizures in children (review),” Evidence-Based Child Health, vol. 8, no. 4, pp. 1376–1485, 2013. View at Publisher · View at Google Scholar · View at Scopus
  151. C. M. Verity, R. Greenwood, and J. Golding, “Long-term intellectual and behavioral outcomes of children with febrile convulsions,” The New England Journal of Medicine, vol. 338, no. 24, pp. 1723–1728, 1998. View at Publisher · View at Google Scholar · View at Scopus
  152. M. Thoresen, “Who should we cool after perinatal asphyxia?” Seminars in Fetal & Neonatal Medicine, vol. 20, no. 2, pp. 66–71, 2015. View at Google Scholar
  153. M. C. Almeida, A. A. Steiner, L. G. S. Branco, and A. A. Romanovsky, “Cold-seeking behavior as a thermoregulatory strategy in systemic inflammation,” European Journal of Neuroscience, vol. 23, no. 12, pp. 3359–3367, 2006. View at Publisher · View at Google Scholar · View at Scopus
  154. Y. Launey, N. Nesseler, Y. Mallédant, and P. Seguin, “Clinical review: fever in septic ICU patients—friend or foe?” Critical Care, vol. 15, no. 3, article 222, 2011. View at Publisher · View at Google Scholar · View at Scopus
  155. B. D. Schmitt, “Fever phobia: misconceptions of parents about fevers,” American Journal of Diseases of Children, vol. 134, no. 2, pp. 176–181, 1980. View at Publisher · View at Google Scholar · View at Scopus
  156. M. Crocetti, N. Moghbeli, and J. Serwint, “Fever phobia revisited: have parental misconceptions about fever changed in 20 years?” Pediatrics, vol. 107, no. 6, pp. 1241–1246, 2001. View at Publisher · View at Google Scholar · View at Scopus
  157. “IVAA-Facts and Figures on Anthroposophic Medicine in Europe,” http://www.ivaa.info/?p=72.
  158. M. Ulbricht, Antipyretische Wirkung eines Körperwarmen Einlaufes, Universität Tübingen, 1991.
  159. GAÄD, Vademecum Anthoposophischer Arzneimittel, Mercurstab, 2010.