Neuroprotective Effect of Paeonol Mediates Anti-Inflammation via Suppressing Toll-Like Receptor 2 and Toll-Like Receptor 4 Signaling Pathways in Cerebral Ischemia-Reperfusion Injured Rats

Figure 5

Effect of paeonol on the number of NF-κB-, IL-1β-, and TNF-α-immunoreactive cells within the cortical penumbra in cerebral ischemia-reperfusion injured rats. (a) The numbers of NF-κB- and IL-1β-immunoreactive cells (arrows) were lower in the paeonol group than in the control group, whereas the number of TNF-α-immunoreactive cells (arrows) did not differ between the paeonol and control groups (200x); (b) the numbers of NF-κB- and IL-1β-immunoreactive cells were significantly lower in the paeonol group than in the control group (), whereas it did not significantly differ between the paeonol and control groups. Data are expressed as mean ± SD. and , and compared with the sham group; and compared with the control group. N: negative control; sham: sham group; control: control group; paeonol: paeonol group.

(a)

(b)