Protective Effects of L-Malate against Myocardial Ischemia/Reperfusion Injury in Rats
Table 1
Hemodynamic assessment under sham-operated conditions.
Groups
LVSP (mmHg)
LVEDP (mmHg)
+ (mmHg/s)
(mmHg/s)
Sham
112.25 ± 5.06
10.88 ± 1.13
4532.13 ± 177.30
−3395.13 ± 254.31
Model
113.50 ± 6.74
10.75 ± 1.04
4592.63 ± 195.67
−3431.63 ± 258.17
DMF
116.00 ± 6.78
11.00 ± 1.31
4512.75 ± 159.85
−3573.50 ± 226.15
LM (15 mg/kg)
116.50 ± 6.14
10.88 ± 1.46
4575.88 ± 190.90
−3464.88 ± 242.18
LM (60 mg/kg)
118 ± 5.29
11.00 ± 1.00
4648.67 ± 209.13
−3446.33 ± 209.13
LM (120 mg/kg)
114.13 ± 7.74
11.00 ± 1.85
4605.38 ± 220.12
−3569.50 ± 274.68
LM (240 mg/kg)
115.30 ± 4.25
11.40 ± 1.27
4659.25 ± 200.57
−3606.21 ± 211.73
LM (480 mg/kg)
116.38 ± 9.78
11.00 ± 1.31
4550.75 ± 199.46
−3526.13 ± 234.33
Data are presented as the means SD. No significant differences were detected among groups. LVSP: left ventricular systolic pressure; LVEDP: left ventricular end-diastolic pressure; : indices of left ventricular contraction; : indices of left ventricular relaxation.