The Extract of Chrysanthemum zawadskii var. latilobum Ameliorates Collagen-Induced Arthritis in Mice

Figure 1

CZ extract’s effect on collagen-induced arthritis (CIA) in mice. DBA/1J mice (male, 5-week-old, and ) were immunized with 100 μg of bovine type II collagen. 23 days later, mice were boosted with an intraperitoneal injection of bovine type II collagen. After the boosting injection of the collagen, CZ extract (1, 10, and 100 mg/kg), methotrexate (0.2 mg/kg), indomethacin (1 mg/kg), and vehicle were taken through the mouth once a day. The arthritis indexes of all four mouse paws were estimated according to the instructions in Section 2. Representative images of paws (a) and arthritis indexes are presented as the mean ± SEM (b) from three separate experiments. and compared with corresponding scores from vehicle-treated CIA mice. CZ, the extract of Chrysanthemum zawadskii var. latilobum; IND, indomethacin; MTX, methotrexate.

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