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Evidence-Based Complementary and Alternative Medicine
Volume 2016, Article ID 3918219, 7 pages
http://dx.doi.org/10.1155/2016/3918219
Research Article

Antioxidant and Hepatoprotective Activity of a New Tablets Formulation from Tamarindus indica L.

1Laboratório de Pesquisa em Fármacos, Universidade Federal do Amapá, 68906-970 Macapá, AP, Brazil
2Departamento de Farmacia, Universidad de Oriente, 90500 Santiago de Cuba, Cuba
3Centro de Toxicología y Biomedicina, Universidad Médica de Santiago de Cuba, 90500 Santiago de Cuba, Cuba
4Laboratório de Nanobiotecnologia Fitofarmacêutica, Universidade Federal do Amapá, 68906-970 Macapá, AP, Brazil

Received 8 December 2015; Revised 25 January 2016; Accepted 8 March 2016

Academic Editor: Pradeep Visen

Copyright © 2016 Jesús Rafael Rodriguez Amado et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Hepatotoxic chemicals damage liver cells primarily by producing reactive oxygen species. The decoction of the leaves of Tamarindus indica L. is used for liver disorders. In this work we evaluated the hepatoprotective activity of a tablet formulation of this plant. Thirty-five Sprague Dawley rats were randomly divided into five groups (). First group (I) is control group, fed with standard diet. Groups II to V (hepatotoxic groups) were subjected to a subcutaneous injection of CCl4 (0.5 mL/kg). Group II was negative control, fed with standard diet; group III was subjected to administration of Silymarin 150 mg/kg and groups IV and V were treated with tablets in dose of 100 mg/kg and 200 mg/kg, respectively. Lipid peroxidation and the activity of superoxide dismutase, catalase, and reduced glutathione were evaluated. Serum levels of alanine aminotransferase, aspartate aminotransferase, gamma-glutamine transferase, alkaline phosphatase, and a lipid profile were evaluated too. The tablets inhibit lipid peroxidation. The redox balance (SOD-CAT-GSH) remains normal in the experimental groups treated with tablets. The liver function using dose of 200 mg/kg of tablets was better than the other experimental groups. These results justify, scientifically, the ethnobotanical use of the leaves of Tamarindus indica L.