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Evidence-Based Complementary and Alternative Medicine
Volume 2016, Article ID 3918219, 7 pages
http://dx.doi.org/10.1155/2016/3918219
Research Article

Antioxidant and Hepatoprotective Activity of a New Tablets Formulation from Tamarindus indica L.

1Laboratório de Pesquisa em Fármacos, Universidade Federal do Amapá, 68906-970 Macapá, AP, Brazil
2Departamento de Farmacia, Universidad de Oriente, 90500 Santiago de Cuba, Cuba
3Centro de Toxicología y Biomedicina, Universidad Médica de Santiago de Cuba, 90500 Santiago de Cuba, Cuba
4Laboratório de Nanobiotecnologia Fitofarmacêutica, Universidade Federal do Amapá, 68906-970 Macapá, AP, Brazil

Received 8 December 2015; Revised 25 January 2016; Accepted 8 March 2016

Academic Editor: Pradeep Visen

Copyright © 2016 Jesús Rafael Rodriguez Amado et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. N. Deshwal, S. H. Kumar, and P. Sharma, “Review on hepatoprotective plants,” International Journal of Pharmaceutical Sciences Research, vol. 7, no. 1, pp. 15–26, 2011. View at Google Scholar
  2. H. E. E.-D. Yossef, A. A. Khedr, and M. Z. Mahran, “Hepatoprotective activity and antioxidant effects of El Nabka (Zizyphus spina-christi) fruits on rats hepatotoxicity induced by carbon tetrachloride,” Nature and Science, vol. 9, no. 2, pp. 1–7, 2011. View at Google Scholar
  3. D. W. Martin, P. A. Mayes, V. W. Rodwell, and D. K. Granner, Harper's Review of Biochemistry, Lange Medical Publication, Los Altos, Calif, USA, 1985.
  4. J. T. Roig, Medicinal Plants, Aromatics and Poisoning of Cuba, Científico Técnica, La Habana, Cuba, 1988 (Spanish).
  5. K. El-Siddig, H. P. M. Gunasena, B. A. Prasad et al., Tamarind, Tamarindus indica, Southampton Centre for Underutilized Crops, Southampton, UK, 2006.
  6. J. Escalona-Arranz, R. Péres-Roses, I. Urdaneta-Laffita, M. Camacho-Pozo, J. Rodríguez-Amado, and I. Licea-Jiménez, “Antimicrobial activity of extracts from Tamarindus indica L. leaves,” Pharmacognosy Magazine, vol. 6, no. 23, pp. 242–247, 2010. View at Publisher · View at Google Scholar · View at Scopus
  7. J. A. Pino, J. C. E. Escalona, I. Licea, R. Pérez, and J. Agüero, “Leaf oil of Tamarindus indica L.,” Journal of Essential Oil Research, vol. 14, no. 3, pp. 187–188, 2002. View at Publisher · View at Google Scholar · View at Scopus
  8. T. Komutarin, S. Azadi, L. Butterworth et al., “Extract of the seed coat of Tamarindus indica inhibits nitric oxide production by murine macrophages in vitro and in vivo,” Food and Chemical Toxicology, vol. 42, no. 4, pp. 649–658, 2004. View at Publisher · View at Google Scholar · View at Scopus
  9. B. Pimple, P. Kadam, N. Badgujar, A. Bafna, and M. Patil, “Protective effect of Tamarindus indica Linn against paracetamol-induced hepatotoxicity in rats,” Indian Journal of Pharmaceutical Sciences, vol. 69, no. 6, pp. 827–831, 2007. View at Publisher · View at Google Scholar · View at Scopus
  10. H. Babich, A. G. Schuck, J. H. Weisburg, and H. L. Zuckerbraun, “Research strategies in the study of the pro-oxidant nature of polyphenol nutraceuticals,” Journal of Toxicology, vol. 2011, Article ID 467305, 12 pages, 2011. View at Publisher · View at Google Scholar · View at Scopus
  11. S. Kulevanova and T. P. Kadifkova, “Antioxidant activity of essential oils of different Wild thymus l. Species,” Bulletin of the Chemists and Technologists of Macedonia, vol. 20, no. 1, pp. 61–66, 2001. View at Google Scholar
  12. H. K. Yeon, P. Juhyun, H. L. Kwan et al., “Ferulic acid protects against carbon tetrachloride induced liver injury in mice,” Toxicology, vol. 282, no. 3, pp. 104–111, 2011. View at Google Scholar
  13. M. A. M. Aboul-Soud, A. M. Al-Othman, G. E. El-Desoky et al., “Hepatoprotective effects of vitamin e/selenium against malathion-induced injuries on the antioxidant status and apoptosis-related gene expression in rats,” Journal of Toxicological Sciences, vol. 36, no. 3, pp. 285–296, 2011. View at Publisher · View at Google Scholar · View at Scopus
  14. R. R. Jesus, L. P. Ariadna, C. s. Julio, M. Q. Humberto, I. C. Antonio, and C. T. Jose, “Optimization of a novel tablets formulation using D-optimal mixture design,” African Journal of Pharmacy and Pharmacology, vol. 9, no. 14, pp. 474–483, 2015. View at Publisher · View at Google Scholar
  15. J. R. Rodríguez, R. P. Rosés, J. C. Escalona, A. Lafourcade, and G. Sierra, “Standardization of the quality control parameters of the Tamarindus indica L. soft extract,” Revista Cubana de Plantas Medicinales, vol. 17, no. 1, pp. 108–114, 2012. View at Google Scholar
  16. R. C. Rowe, Ed., Handbook of Pharmaceutical Excipient, Pharmaceutical Press, London, UK; American Pharmacists Association, Washington, DC, USA, 2009.
  17. Guide for the Handling of the Laboratory Animal, International Council for Laboratory Animals Sciences, Commision of Live and Sciences, Mexico, DF, Mexico, 2002.
  18. B. Saraswat, P. K. S. Visen, G. K. Patnaik, and B. N. Dhawan, “Anticholestic effect of picroliv, active hepatoprotective principle of Picrorhiza kurrooa, against carbon tetrachloride induced cholestasis,” Indian Journal of Experimental Biology, vol. 31, no. 4, pp. 316–318, 1993. View at Google Scholar · View at Scopus
  19. W. H. Vogel, B. A. Scholkens, J. Sandow, and G. Muller, Drug Discovery and Evaluation, Pharmacological Assay, Spinger, New York, NY, USA, 2002.
  20. O. Sorg, “Oxidative stress: a theoretical model or a biological reality?” Comptes Rendus-Biologies, vol. 327, no. 7, pp. 649–662, 2004. View at Publisher · View at Google Scholar · View at Scopus
  21. D. Han, S. Loukianoff, L. McLaughlin, K. S. Chandan, L. P. Facsm, and O. Fos, Handbook of Oxidants and Antioxidants in Exercise, Elsevier Science, Amsterdam, The Netherlands, 2000.
  22. C. C. Allain, N. Richmond, and P. Rosechloy, “Cholestrol enzymatic colorimetric test,” Chemical Clinics, vol. 19, no. 20, pp. 1350–1361, 1974. View at Google Scholar
  23. R. Lee and D. Nieman, Nutritional Assessment, Mosby, St. Louis, Mo, USA, 2nd edition, 1996.
  24. R. K. Murray, D. K. Granner, P. H. Mayer, and V. W. Rodwel, Harper's Illustrated Biochemestry, McGraw-Hill, New York, NY, USA, 26th edition, 2003.
  25. T. F. Slater, “Necrogenic action of CCl4 in the rat: a speculative mechanism based on activation,” Nature, vol. 209, no. 18, pp. 36–40, 1966. View at Google Scholar
  26. N. Kaplowitz, T. Y. Aw, F. R. Simon, and A. Stolz, “Drug-induced hepatotoxicity,” Annals of Internal Medicine, vol. 104, no. 6, pp. 826–839, 1986. View at Publisher · View at Google Scholar · View at Scopus
  27. P. Bhatia, R. Prakash, and N. T. Prakash, “Enhanced antioxidant properties as a function of selenium uptake by edible mushrooms cultivated on selenium-accumulated waste post-harvest wheat and paddy residues,” International Journal of Recycling of Organic Waste in Agriculture, vol. 3, no. 4, pp. 127–132, 2014. View at Publisher · View at Google Scholar · View at Scopus
  28. H. Farghali, L. Kameniková, S. Hynie, and E. Kmonicková, “Silymarin effects on intracellular calcium and cytotoxicity: a study in perfused rat hepatocytes after oxidative stress injury,” Pharmacological Research, vol. 41, no. 2, pp. 231–237, 2000. View at Publisher · View at Google Scholar · View at Scopus
  29. D. Bhattacharya, R. Mukherjee, S. Pandit, N. Das, and T. K. Sur, “Prevention of carbon tetrachloride induced hepatotoxicity in rats by Himoliv®, a polyherbal formulation,” Indian Journal of Pharmacology, vol. 35, pp. 183–185, 2003. View at Google Scholar
  30. P. Saha, K. Mazumder, P. K. Haldar, A. Bala, B. Kar, and S. Naskar, “Evaluation of hepatoprotective activity of Cucurbita maxima aerial parts,” Journal of Herbal Medicine and Toxicology, vol. 5, no. 1, pp. 17–22, 2011. View at Google Scholar
  31. H. Hajimehdipoor, R. Shahrestani, and M. Shekarchi, “Investigating the synergistic antioxidant effects of some flavonoid and phenolic compounds,” Research Journal of Pharmacognosy, vol. 1, no. 3, pp. 35–40, 2014. View at Google Scholar
  32. K. E. Hill, T. J. Montine, A. K. Motley, X. Li, J. M. May, and R. F. Burk, “Combined deficiency of vitamins E and C causes paralysis and death in guinea pigs,” American Journal of Clinical Nutrition, vol. 77, no. 6, pp. 1484–1488, 2003. View at Google Scholar · View at Scopus
  33. G. Gupta, A. S. More, R. R. Kumari et al., “Protective effect of alcoholic extract of Entada pursaetha DC against CCl4-induced hepatotoxicity in rats,” Indian Journal of Experimental Biology, vol. 52, no. 3, pp. 207–214, 2014. View at Google Scholar · View at Scopus
  34. M. E. Omar, S. Abdel, A. A. Sleem, and M. S. Nermeen, “Hepatoprotective effects of citric acid and aspartame on carbon tetrachloride-induced hepatic damage in rats,” EXCLI Journal, vol. 8, pp. 41–49, 2009. View at Google Scholar
  35. C. C. Liolios, G. T. Sotiroudis, and I. Chinou, “Fatty acids, sterols, phenols and antioxidant activity of Phoenix theophrasti fruits growing in Crete, Greece,” Plant Foods for Human Nutrition, vol. 64, no. 1, pp. 52–61, 2009. View at Publisher · View at Google Scholar · View at Scopus
  36. M. Ismail, A. Mariod, G. Bagalkotkar, and H. S. Ling, “Fatty acid composition and antioxidant activity of oils from two cultivars of Cantaloupe extracted by supercritical fluid extraction,” Grasas y Aceites, vol. 61, no. 1, pp. 37–44, 2010. View at Publisher · View at Google Scholar
  37. S.-C. Lee, C.-C. Tsai, J.-C. Chen, C.-C. Lin, M.-L. Hu, and S. Lu, “The evaluation of reno- and hepato-protective effects of Huai-Shan-Yao (Rhizome dioscoreae),” American Journal of Chinese Medicine, vol. 30, no. 4, pp. 609–616, 2002. View at Publisher · View at Google Scholar · View at Scopus
  38. L. R. Hai, “Potential synergy of phytochemicals in cancer prevention: mechanism of action,” The Journal of Nutrition, vol. 134, no. 12, supplement, pp. 3479S–3485S, 2004, Proceedings of the International Research Conference on Food, Nutrition, and Cancer. View at Google Scholar
  39. P. Pedrielli and L. H. Skibsted, “Antioxidant synergy and regeneration effect of quercetin, (−)-epicatechin, and (+)-catechin on α-tocopherol in homogeneous solutions of peroxidating methyl linoleate,” Journal of Agricultural and Food Chemistry, vol. 50, no. 24, pp. 7138–7144, 2002. View at Publisher · View at Google Scholar · View at Scopus
  40. E. Finotti, M. D'Ambrosio, F. Paoletti, V. Vivanti, and G. Quaglia, “Synergistic effects of α-tocopherol, β-sitosterol and squalene on antioxidant activity assayed by crocin bleaching method,” Nahrung, vol. 44, no. 5, pp. 373–374, 2000. View at Google Scholar
  41. R. Ricciarelli, J.-M. Zingg, and A. Azzi, “Vitamin E: protective role of a Janus molecule,” The FASEB Journal, vol. 15, no. 13, pp. 2314–2325, 2001. View at Publisher · View at Google Scholar · View at Scopus
  42. A. Sonbolia, P. Salehib, K. M. Reza, and E. M. Nejad, “Antibacterial and antioxidant activity and essential oil composition of grammosciadium scabridum boiss,” Zeitschrift für Naturforschung, vol. 60, no. 7-8, pp. 534–538, 2005. View at Google Scholar
  43. J. H. Chen and C.-T. Ho, “Antioxidant activities of caffeic acid and its related hydroxycinnamic acid compounds,” Journal of Agricultural and Food Chemistry, vol. 45, no. 7, pp. 2374–2378, 1997. View at Publisher · View at Google Scholar · View at Scopus
  44. Y.-C. Chan, S.-C. Chang, S.-Y. Liu, H.-L. Yang, Y.-C. Hseu, and J.-W. Liao, “Beneficial effects of yam on carbon tetrachloride-induced hepatic fibrosis in rats,” Journal of the Science of Food and Agriculture, vol. 90, no. 1, pp. 161–167, 2010. View at Publisher · View at Google Scholar · View at Scopus