Effects of Safflower Yellow on the Treatment of Severe Sepsis and Septic Shock: A Randomized Controlled Clinical Trial

Table 3

Clinical secondary outcomes.

Secondary outcome factors	Study group	Control group	value
	()	()
Heart rate (beats/min)
Before intervention	122.80 ± 20.89	113.22 ± 27.25	0.106
72 h after intervention	91.63 ± 17.96	112.38 ± 29.13	0.042
Mean artery pressure (mmHg)
Before intervention	70.43 ± 19.84	74.94 ± 19.25	0.297
72 h after intervention	81.35 ± 15.48	75.02 ± 18.02	0.093
Respiratory frequency (breaths/min)
Before intervention	25.55 ± 8.19	25.78 ± 6.65	0.282
72 h after intervention	19.87 ± 5.39	23.36 ± 6.05	0.019
Arterial partial pressure of oxygen (PaO2, mmHg)
Before intervention	82.15 ± 45.99	74.51 ± 35.37	0.651
72 h after intervention	107.83 ± 41.51	81.41 ± 39.97	0.015
Leucocyte counts (10^9/L)
Before intervention	16.22 ± 8.72	14.82 ± 8.57	0.926
72 h after intervention	12.05 ± 7.75	17.21 ± 8.16	0.013
Urinary production per hour (mL/hour)
Before intervention	68.28 ± 40.40	74.12 ± 52.99	0.555
72 h after intervention	130.14 ± 93.53	65.7 ± 41.52	0.002
Platelet counts (10^9/L)
Before intervention	163.38 ± 120.02	155.83 ± 84.91	0.454
72 h after intervention	156.10 ± 104.79	108.26 ± 64.13	0.018
Lactate level (mmol/L)
Before intervention	4.68 ± 3.32	4.61 ± 3.55	0.937
72 h after intervention	2.48 ± 2.26	4.40 ± 3.41	0.006
Bilirubin (µmol/L)
Difference before and 72 h after intervention	13.65 (4.50, 53.10)	17.00 (3.50, 249.63)	0.844
Creatinine (mmol/L)
Before intervention	137.22 ± 58.62	136.80 ± 65.47	0.976
72 h after intervention	126.52 ± 68.61	160.73 ± 92.27	0.06
Rate of voluntary termination of treatment (%)	32.5% (13/40)	23.80% (10/42)	0.381
Days of ICU hospitalization (days)	8.23 ± 5.25	8.12 ± 10.19	0.951
Days of mechanical ventilation (days)	3.60 ± 4.14	3.70 ± 4.29	0.928