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Evidence-Based Complementary and Alternative Medicine
Volume 2016, Article ID 4097398, 8 pages
Research Article

Prevention and Therapeutic Effects and Mechanisms of Tanshinone IIA Sodium Sulfonate on Acute Liver Injury Mice Model

1Department of Oncology, The Second Affiliated Hospital of Soochow University, Suzhou 215004, China
2Department of Radiation Genetics, School of Radiation Medicine and Protection, Soochow University School of Medicine, Suzhou 215123, China
3Department of Emergency, Suzhou Kowloon Hospital, Shanghai Jiao Tong University School of Medicine, Suzhou 215000, China
4Department of Radiation Oncology, The Affiliated Hospital of Jiangnan University, Wuxi 214062, China

Received 29 December 2015; Revised 31 March 2016; Accepted 7 April 2016

Academic Editor: Shun-Wan Chan

Copyright © 2016 Lunjie Lu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Tanshinone IIA sodium sulfonate (TSS) is a water-soluble derivative of tanshinone IIA, which is the main pharmacologically active component of Salvia miltiorrhiza. This study aimed to verify the preventive and therapeutic effects of TSS and its combined therapeutic effects with magnesium isoglycyrrhizinate (MI) in D-galactosamine- (D-Gal-) induced acute liver injury (ALI) in mice. The potential regulatory mechanisms of TSS on ALI were also examined. Our results may provide a basis for the development of novel therapeutics for ALI.