Prevention and Therapeutic Effects and Mechanisms of Tanshinone IIA Sodium Sulfonate on Acute Liver Injury Mice Model

Figure 1

Effects of TSS pretreatment, single-drug treatment, and combined treatment with MI on mice with D-Gal-induced ALI. Mice were pretreated with 100 mg⋅kg⁻¹ TSS 2 h before D-Gal (450 mg⋅kg⁻¹) exposure; otherwise, they were treated with 100 mg⋅kg⁻¹ TSS or 100 mg⋅kg⁻¹ TSS together with 45 mg⋅kg⁻¹ MI 2 h after D-Gal exposure. At 24 h after the treatments were administered, blood samples were harvested, and (a) alanine aminotransferase (ALT) and (b) aspartate aminotransferase (AST) levels were determined. Data were expressed as mean ± SD, n = 5. < 0.05 compared with the control group using Student’s -test. < 0.05 compared with the D-Gal group using one-way ANOVA followed by Dunnett’s analysis.

(a)

(b)