Research Article
Prevention and Therapeutic Effects and Mechanisms of Tanshinone IIA Sodium Sulfonate on Acute Liver Injury Mice Model
Figure 3
Effects of TSS pretreatment or treatment on cyclin D1 expression in D-Gal-exposed mouse liver. Cyclin D1 expression was detected through immunohistochemical staining. The dark-brown nucleus indicated cyclin D1-positive cells. (a) Mice treated with physiological saline; (b) mice exposed to D-Gal (450 mg⋅kg−1); (c) mice pretreated with TSS (100 mg⋅kg−1) before D-Gal exposure; (d) mice treated with TSS (100 mg⋅kg−1) alone after D-Gal exposure; (e) mice treated with TSS (100 mg⋅kg−1) and MI (45 mg⋅kg−1) after D-Gal exposure. Representative liver sections of each group are shown (original magnification: 400x). compared with the D-Gal group; compared with the D-Gal group, using one-way ANOVA followed by Dunnett’s analysis.
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