Biological Evaluation and Docking Analysis of Daturaolone as Potential Cyclooxygenase Inhibitor

Figure 3

Effect of compound 1 and diclofenac on acetic acid-induced writhing responses in mice. Saline (10 mL/kg), compound 1 (1.0, 3.0, 10.0, and 30.0 mg/kg), or diclofenac (1.0, 3.0, 10.0, and 30.0 mg/kg) was administrated intraperitoneally (i.p.) 30 min before acetic acid injection (0.1 mL; i.p.). Values reported as percentage (%) of inhibition of writhings are expressed as log dose (mg/kg) ± SEM (). , , and .