Cardiovascular Effects of the Essential Oil of Croton argyrophylloides in Normotensive Rats: Role of the Autonomic Nervous System

Figure 2

Maximal changes in mean aortic pressure (ΔMAP max, (a)) and heart rate (ΔHR max, (b)) elicited by intravenous (i.v.) injections of increasing bolus doses (1–20 mg/kg) of the essential oil of Croton argyrophylloides (EOCA) in conscious rats subjected to i.v. pretreatment with saline (Veh; 1 mL/kg), atenolol (Ate; 1.5 mg/kg), hexamethonium (Hex; 30 mg/kg), or methylatropine (Met; 1 mg/kg). Values are means of changes expressed as a percentage of baseline values. Vertical bars indicate SEM (5–7 rats per group). by Dunnett’s test with respect to basal values. by two-way ANOVA with respect to conscious, saline-pretreated rats.

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(b)