Antiobesity Effects of Unripe Rubus coreanus Miquel and Its Constituents: An In Vitro and In Vivo Characterization of the Underlying Mechanism
Table 2
The effects of uRCB on body weight, food intake, adipose tissue weight, and serum lipid parameters in HFD-induced obese mice.
ND
HFD
uRCB 10 mg/kg
uRCB 50 mg/kg
Initial body weight (g)
20.64 ± 0.08
20.92 ± 0.09
20.89 ± 0.31
20.78 ± 0.23
Final body weight (g)
26.63 ± 0.49
40.05 ± 0.65
31.67 ± 0.24
30.05 ± 0.25
Body weight gain (g)
5.99 ± 0.47
19.13 ± 0.71
10.78 ± 0.42
8.90 ± 0.43
Food intake (g/day)
2.75 ± 0.04
2.16 ± 0.11
2.48 ± 0.00
2.68 ± 0.09
FER
2.22 ± 0.17
7.96 ± 0.32
4.31 ± 0.17
4.27 ± 0.41
Organ weight
Epididymal fat (g)
0.49 ± 0.01
2.44 ± 0.04
1.67 ± 0.09
1.48 ± 0.04
Perirenal fat (g)
0.16 ± 0.01
1.05 ± 0.03
0.67 ± 0.03
0.67 ± 0.01
Liver (g)
1.29 ± 0.04
1.51 ± 0.07
1.19 ± 0.02
1.14 ± 0.02
Blood parameter
GOT (U/L)
95.20 ± 2.57
182.40 ± 14.85
103.83 ± 2.33
90.60 ± 1.61
GPT (U/L)
29.2 ± 3.31
42.80 ± 2.47
38.17 ± 1.76
29.80 ± 0.75
Creatinine (mg/dL)
0.32 ± 0.02
0.16 ± 0.01
0.15 ± 0.01
0.10 ± 0.00
BUN (mg/dL)
27.10 ± 1.04
27.88 ± 0.87
26.65 ± 0.57
27.28 ± 0.37
Glucose (mg/dL)
187.20 ± 5.48
300.50 ± 12.52
224.67 ± 4.32
182.25 ± 5.32
TC (mg/dL)
124.20 ± 1.73
195.20 ± 3.11
181.67 ± 3.37
171.50 ± 2.27
TG (mg/dL)
173.00 ± 6.14
247.20 ± 10.84
188.67 ± 5.02
186.80 ± 5.98
HDL-C (mg/dL)
76.67 ± 1.19
57.00 ± 1.10
61.67 ± 2.96
75.67 ± 2.03
LDL-C (mg/dL)
22.13 ± 2.42
83.33 ± 2.68
80.40 ± 3.90
72.13 ± 3.39
FER (food efficiency ratio) = body weight gain/food intake LDL-C (LDL-cholesterol) = total cholesterol − HDL-cholesterol − triglyceride/5 Values are expressed as mean ± SE (). P < 0.05 and P < 0.001 compared with the ND group; P < 0.05, P < 0.01, and P < 0.001 compared with the HFD group.
