Metabolomic Analysis of Biochemical Changes in the Plasma of High-Fat Diet and Streptozotocin-Induced Diabetic Rats after Treatment with Isoflavones Extract of Radix Puerariae
Table 4
Effects of PTIF (421 mg/kg) on amino acids in high-fat diet and STZ-induced diabetic rats (μmol/L).
Amino acid
Normal
Diabetic
Diabetic + PTIF
Serine
103.1 ± 30.4
117.7 ± 35.8
115.3 ± 18.2
Glutamate
29.3 ± 7.3
61.0 ± 22.3
42.9 ± 8.1#
Glycine
111.4 ± 28.3
111.4 ± 20.4
104.6 ± 17.1
Histidine
158.7 ± 27.0
173.1 ± 24.9
208.6 ± 42.8
Arginine
226.0 ± 56.0
347.9 ± 99.8
349.4 ± 59.1
Threonine
89.7 ± 24.1
81.0 ± 18.4
96.3 ± 16.7
Alanine
185.4 ± 37.0
213.2 ± 42.7
171.4 ± 35.6
Proline
84.7 ± 28.0
99.0 ± 34.7
69.1 ± 9.4
Tyrosine
38.0 ± 10.6
59.4 ± 18.9
45.9 ± 8.1
Valine
50.6 ± 12.7
107.2 ± 32.2
123.0 ± 22.6
Methionine
29.4 ± 9.3
33.5 ± 12.8
28.9 ± 5.2
Lysine
86.0 ± 14.5
70.9 ± 11.1
78.4 ± 17.1
Isoleucine
25.7 ± 6.5
68.5 ± 11.3
56.9 ± 14.1
Leucine
42.1 ± 10.7
104.8 ± 17.8
84.0 ± 21.9#
Phenylalanine
40.5 ± 9.8
52.9 ± 13.6
56.6 ± 10.1
All data were expressed as mean ± SD. One-way analysis of variance (ANOVA) was used for significance analysis. indicate a significant difference as compared with normal rats; # indicate a significant difference as compared with diabetic rats.
