Antcin K, a Triterpenoid Compound from Antrodia camphorata, Displays Antidiabetic and Antihyperlipidemic Effects via Glucose Transporter 4 and AMP-Activated Protein Kinase Phosphorylation in Muscles

Figure 3

Effects of antcin K (AnK) on (a) blood glucose levels, (b) blood triglycerides levels, (c) blood total cholesterol levels, (d) insulin levels, (e) leptin levels, (f) adiponectin levels, and (g) blood FFA levels at week 12. Mice were fed with 45% high-fat diet (HF) or low-fat diet (CON) for 12 weeks. After 8 weeks of induction, the HF mice were treated with vehicle, or antcin K, or fenofibrate (Feno), or metformin (Metf) accompanied with HF diet for 4 weeks. All values are means ± SE (). and compared with the control (CON) group; , , and compared with the high-fat diet plus vehicle (distilled water) (HF) group by ANOVA. AnK (AnK1, AnK2, or AnK3, 10, 20, or 40 mg/kg body wt); fenofibrate (Feno, 250 mg/kg body wt); metformin (Metf, 300 mg/kg body wt). FFA, plasm free fatty acid; visceral fat represented epididymal WAT plus retroperitoneal WAT.

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