Antcin K, a Triterpenoid Compound from Antrodia camphorata, Displays Antidiabetic and Antihyperlipidemic Effects via Glucose Transporter 4 and AMP-Activated Protein Kinase Phosphorylation in Muscles

Figure 6

GLUT4 protein contents in skeletal muscle or phospho-Akt/t-Akt or phospho-AMPK (Thr¹⁷²)/t-AMPK in liver and skeletal muscle of the mice by oral gavage antcin K (AnK): (a) representative image; (b) quantification of the GLUT4 expression levels, the ratio of phospho-AMPK to total-AMPK, or phospho-Akt/t-Akt expression levels (mean ± SE, ). Protein was separated by 12% SDS PAGE detected by Western blot. compared with the control (CON) group; and compared with the high-fat-diet plus vehicle (distilled water) (HF) group. Antcin K (AnK1, AnK2, or AnK3, 10, 20, or 40 mg/kg body weight, resp.); Feno, fenofibrate (250 mg/kg body weight); Metf, metformin (300 mg/kg body weight).

(a)

(b)