Acute and Subacute Toxicological Evaluation of the Aerial Extract of Monsonia angustifolia E. Mey. ex. A. Rich in Wistar Rats
Table 2
Effect of 28-day administration of standardized extract of Monsonia angustifolia on haematological parameters of Wistar rats.
Parameters
Control
Extract (mg/kg body weight)
75
150
300
HGB (g/dL)
15.30 ± 0.62
15.67 ± 1.75
15.63 ± 1.05
15.23 ± 1.36
Haematocrit (L/L)
0.46 ± 0.02
0.49 ± 0.36
0.48 ± 0.02
0.45 ± 0.01
MCV (fl)
59.20 ± 0.69
58.93 ± 1.46
60.97 ± 1.66
62.03 ± 1.45
MCH (pg)
18.77 ± 0.25
18.67 ± 0.93
18.83 ± 0.40
19.03 ± 0.65
MCHC (g/dL)
31.6 ± 0.69
31.93 ± 0.75
31.23 ± 1.22
30.13 ± 0.38
RCDW (%)
12.67 ± 0.31
12.70 ± 0.46
12.83 ± 0.40
13.07 ± 0.49
RBC (1012/L)
7.67 ± 0.37
8.31 ± 0.46
8.22 ± 1.21
8.01 ± 0.88
Platelets (109/L)
889.7 ± 1.15
854.0 ± 1.53
955.3 ± 1.00
1010.0 ± 1.41
MPV
7.90 ± 0.10
8.00 ± 0.36
7.60 ± 0.10
7.57 ± 0.40
WBC (109/L)
13.44 ± 1.04
17.42 ± 0.99
20.42 ± 0.48
24.49 ± 0.53
Neutrophils (109/L)
10.67 ± 0.25
10.97 ± 0.89
10.18 ± 0.21
9.53 ± 0.66
Monocytes (109/L)
57.00 ± 1.83
56.05 ± 1.77
54.75 ± 0.21
55.50 ± 1.82
Eosinophils (109/L)
2.47 ± 0.72
2.23 ± 0.39
2.33 ± 0.41
2.50 ± 0.91
Basophils (109/L)
0.60 ± 0.26
0.40 ± 030
0.53 ± 0.21
0.57 ± 0.51
Lymphocytes
25.47 ± 0.02
26.40 ± 1.41
26.80 ± 3.25
27.73 ± 0.99
Data are means ± SEM ( = 6). Values carrying superscripts are significantly different () from the control. RBC: red blood cell; HGB: haemoglobin; MCV: mean corpuscular volume; MCH: mean corpuscular haemoglobin; MCHC: mean corpuscular haemoglobin concentration; RCDW: red cell distribution width; MPV: mean platelet volume; WBC: white blood cell.
