The Role of Hippocampal Estradiol Receptor-α in a Perimenopausal Affective Disorders-Like Rat Model and Attenuating of Anxiety by Electroacupuncture

Figure 4

Comparisons between mean and standard error of serum steroid hormones (a–c) and estradiol receptor-α immunoreactive neurons’ counts in CA1 hippocampus (d) to evaluate effect of electroacupuncture and estradiol on perimenopausal affective disorders in rats. Representative immunofluorescent photos indicating estradiol receptor-α immunoreactive neurons in CA1 hippocampus for evaluation of the effect of electroacupuncture and estradiol on perimenopausal affective disorders in rats (e). Significant differences between groups are shown by lines (). INT, intact group; CUS, chronic unpredictable stress group; OVX, ovariectomy group; O + C, ovariectomy and chronic unpredictable stress group; EA, electroacupuncture; E₂, estradiol.

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