Evidence-Based Complementary and Alternative Medicine

Research Article

The Role of Hippocampal Estradiol Receptor-α in a Perimenopausal Affective Disorders-Like Rat Model and Attenuating of Anxiety by Electroacupuncture

Table 2

Comparisons between two types of therapeutics on attenuating of anxiety and depression behaviors in perimenopausal affective disorders in rats based on various patterns of behavior tests.
Tests and patterns OVX CUS OVX + CUS
ControlE2EAControlE2EAControlE2EA
Open field test         
 Line crossings+−−+−+−+−
 Grooming−+−−−−−−−
 Peripheral part entries−+−−+−−+−
 Central part entries+−+−−+−−−
 Rearing in peripheral part++++−+−+−
 Rearing in central part+−−+−−+−−
 Duration in central part+−+−−++−−
 Grooming time−+−=++++−
Elevated plus maze test         
 Close arm entries−+−−+−=−+
 Total arm entries−+−−+−−−+
 Open arm entries++++−++++
 Stretched-attend postures−+−−++−−+
 Rearing+−−+−+++−
 Grooming−−−−++−−+
 Open arm duration ratio++++−++++
Overall antianxiety effect+1+3−5−2−3+5−2−1−3
INT, intact; OVX, ovariectomy; CUS, chronic unpredictable stress; Co, control; E2, estradiol; EA, electroacupuncture.
Differences of mean of behavior patterns between treatments and pretreatment control in each group: =, no effect; +, antianxiety effect; −, anxiety effect.