Research Article
The Effect of Vinpocetine on Human Cytochrome P450 Isoenzymes by Using a Cocktail Method
Table 1
The IC50 values of vinpocetine on the activities of five major CYP isoenzymes in human liver microsomes.
| Isoenzymes | Substrates | Metabolites | IC50 (μM) |
| CYP3A4 | Testosterone | 6β-Hydroxytestosterone | 107.1 | CYP2C9 | Tolbutamide | 4-Hydroxytolbutamide | 68.96 [95% CI: 49.14–96.79] | CYP2C19 | Omeprazole | 5-Hydroxyomeprazole | 285.1 | CYP2D6 | Dextromethorphan | Dextrorphan | 104.4 | CYP2E1 | Chlorzoxazone | 6-Hydrxychlorzoxazone | 2837 |
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