The Effect of Vinpocetine on Human Cytochrome P450 Isoenzymes by Using a Cocktail Method

<table class="table-group" id="tab1"><tr><td><table class="table"><tr><td class="thead-hr" colspan="4"><hr/></td></tr><tr class="thead"><td class="align_left">Isoenzymes</td><td class="align_center">Substrates</td><td class="align_center">Metabolites</td><td class="align_center">IC<sub>50</sub> (<i>μ</i>M)</td></tr><tr><td class="thead-hr" colspan="4"><hr/></td></tr><tr><td class="align_left">CYP3A4</td><td class="align_center">Testosterone</td><td class="align_center">6<i>β</i>-Hydroxytestosterone</td><td class="align_center">107.1</td></tr><tr><td class="align_left">CYP2C9</td><td class="align_center">Tolbutamide</td><td class="align_center">4-Hydroxytolbutamide</td><td class="align_center">68.96 [95% CI: 49.14–96.79]</td></tr><tr><td class="align_left">CYP2C19</td><td class="align_center">Omeprazole</td><td class="align_center">5-Hydroxyomeprazole</td><td class="align_center">285.1</td></tr><tr><td class="align_left">CYP2D6</td><td class="align_center">Dextromethorphan</td><td class="align_center">Dextrorphan</td><td class="align_center">104.4</td></tr><tr><td class="align_left">CYP2E1</td><td class="align_center">Chlorzoxazone</td><td class="align_center">6-Hydrxychlorzoxazone</td><td class="align_center">2837</td></tr><tr class="table-tr"><td colspan="4"><hr class="tbody-hr"/></td></tr></table></td></tr></table>

The IC<sub>50</sub> values of vinpocetine on the activities of five major CYP isoenzymes in human liver microsomes.

Evidence-Based Complementary and Alternative Medicine

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Table 1

Table 1: The Effect of Vinpocetine on Human Cytochrome P450 Isoenzymes by Using a Cocktail Method 