The Effect of Vinpocetine on Human Cytochrome P450 Isoenzymes by Using a Cocktail Method

Table 2

Effects of vinpocetine on five major CYP-specific metabolite formations in human liver microsomes. Each data point represents the mean value (±SD) of triplicate determinations.

Isoenzymes (specific metabolites)	Metabolite formation (% of control)
	Vinpocetine (μg/mL)
	0.1	0.3	1.0	3.0	10.0	30.0	100.0
CYP3A4 (6β-hydroxytestosterone)	103.1 ± 7.1	97.6 ± 7.5	93.6 ± 10.5	81.7 ± 5.8	71.1 ± 8.2	60.1 ± 6.2	56.4 ± 8.6
CYP2C9 (4-hydroxytolbutamide)	104.6 ± 8.3	102.7 ± 7.4	96.6 ± 4.6	88.7 ± 6.5	87.5 ± 6.0	60.9 ± 7.3	44.9 ± 6.2
CYP2C19 (5-hydroxyomeprazole)	106.7 ± 9.6	99.3 ± 5.7	100.5 ± 5.6	93.5 ± 4.0	81.5 ± 5.2	76.1 ± 6.4	66.8 ± 6.7
CYP2D6 (dextrorphan)	109.4 ± 7.4	98.3 ± 5.4	95.7 ± 7.1	90.7 ± 6.8	83.8 ± 6.7	64.0 ± 3.9	53.8 ± 6.1
CYP2E1 (6-hydrxychlorzoxazone)	104.4 ± 10.5	102.8 ± 5.4	98.8 ± 8.9	95.2 ± 6.2	90.6 ± 5.2	89.2 ± 9.2	84.5 ± 9.1