A Herbal Formula, CGXII, Exerts Antihepatofibrotic Effect in Dimethylnitrosamine-Induced SD Rat Model

Figure 2

Histopathological analysis and immunohistochemical staining. Following DMN injection, rats were orally given distilled water, CGXII (50 mg and 100 mg/kg), or DDB (50 mg/kg) daily for 4 weeks. The liver tissues were examined using hematoxylin and eosin (a), Masson’s trichrome (b), and immunohistochemistry for α-SMA (c); pathophysiologic examinations were performed under light microscopy (100x magnification). The inflammation scores (d), METAVIR scores (e), and the α-SMA positive cells (f) were analyzed. Data are expressed as the mean ± SD (). , compared with the normal group; and , compared with the DMN group.

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