Serum Protein KNG1, APOC3, and PON1 as Potential Biomarkers for Yin-Deficiency-Heat Syndrome

Table 2

Downregulated serum proteins in YDH syndrome group quantified by iTRAQ-based proteomics and the ratios to the control group.

Protein ID	Gene name	Protein name	M/C (114/113)			M/C (116/115)
			Run 1	Run 2	Mean	Run 1	Run 2	Mean
P02091	Hbb	Hemoglobin subunit beta-1	0.71	0.70	0.71	0.67	0.70	0.68
P05545	Serpina3k	Serine protease inhibitor A3K	0.66	0.64	0.65	0.65	0.70	0.68
Q6IE52	Mug2	Murinoglobulin-2	0.67	0.75	0.71	0.42	0.73	0.58
P15978	RT1-Aw2	Class I histocompatibility antigen	0.73	0.61	0.67	0.58	0.60	0.59
P36953	Afm	Afamin	0.54	0.45	0.49	0.74	0.69	0.72
Q62894	Ecm1	Extracellular matrix protein 1	0.77	0.55	0.66	0.52	0.51	0.52
O88201	Clec11a	C-type lectin domain family 11 member A	0.77	0.53	0.65	0.32	0.72	0.52
P55314	C8b	Complement component C8 beta chain	0.74	0.74	0.74	0.37	0.47	0.42
P14630	Apom	Apolipoprotein M	0.64	0.44	0.54	0.53	0.60	0.57
P35859	Igfals	Insulin-like growth facto	0.50	0.58	0.54	0.44	0.58	0.51
P14046	A1i3	Alpha-1-inhibitor 3	0.48	0.56	0.52	0.67	0.34	0.50
Q64268	Serpind1	Heparin cofactor 2	0.74	0.70	0.72	0.24	0.31	0.27
Q68FP1	Gsn	Gelsolin	0.56	0.58	0.57	0.31	0.52	0.41
Q00918	Ltbp1	Latent-transforming growth factor	0.44	0.50	0.47	0.44	0.47	0.46
P23680	Apcs	Serum amyloid P-component	0.73	0.69	0.71	0.22	0.21	0.22
Q8R2H5	Gpld1	Phosphatidylinositol	0.53	0.69	0.61	0.30	0.31	0.31
P31211	Serpina6	Corticosteroid-binding globulin	0.54	0.50	0.52	0.36	0.36	0.36
Q9QUH3	Apoa5	Apolipoprotein A-V	0.53	0.53	0.53	0.39	0.28	0.33
P48199	Crp	C-reactive protein	0.72	0.72	0.72	0.10	0.19	0.14
O70535	Lifr	Leukemia inhibitory factor receptor	0.33	0.40	0.36	0.46	0.52	0.49
P55797	Apoc4	Apolipoprotein C-IV	0.33	0.53	0.43	0.43	0.41	0.42
P18292	F2	Prothrombin	0.65	0.64	0.65	0.13	0.25	0.19
P07092	Serpine2	Glia-derived nexin	0.52	0.37	0.44	0.42	0.14	0.28
P19939	Apoc1	Apolipoprotein C-I	0.34	0.35	0.34	0.32	0.34	0.33
P07808	Npy	Pro-neuropeptide Y	0.63	0.29	0.46	0.13	0.24	0.19
O08770	Gp5	Platelet glycoprotein V	0.37	0.56	0.46	0.17	0.14	0.15
P55159	Pon1	Serum paraoxonase/arylesterase 1	0.27	0.19	0.23	0.31	0.24	0.28
P06759	Apoc3	Apolipoprotein C-III	0.41	0.28	0.35	0.13	0.11	0.12
P04638	Apoa2	Apolipoprotein A-II	0.11	0.13	0.12	0.25	0.27	0.26

M, model group; C, control group. 114/113 and 116/115, two biological replicates; Run 1 and Run 2, two technical replicates.