Serum Protein KNG1, APOC3, and PON1 as Potential Biomarkers for Yin-Deficiency-Heat Syndrome

Table 5

Diagnostic value for YDH syndrome detection of the individual markers and KNG1, APOC3, and PON1 combination.

Protein	Sensitivity (%)	Specificity (%)	PPV (%)	NPV (%)	AUC	95% CI	p value
KNG1	100.0	70.0	75.0	100.0	0.886	0.741–0.966	p < 0.0001
APOC3	72.0	75.0	72.2	75.0	0.771	0.606–0.891	p = 0.0006
PON1	83.3	70.0	71.4	82.4	0.767	0.601–0.888	p = 0.0009
KNG1 + APOC3 + PON1	100.0	85.0	85.7	100.0	0.950	0.826–0.994	p < 0.0001

AUC, area under the curve; PPV, positive predictive values; NPV, negative predictive values; 95% CI, 95% confidence interval.