Selective Inhibition of Bakuchicin Isolated from Psoralea corylifolia on CYP1A in Human Liver Microsomes

Figure 3

Lineweaver-Burk plot in pooled liver microsome obtained from a kinetic study of CYP1A-catalyzed phenacetin O-deethylation following 60 min of incubation with bakuchicin at 0 (●), 0.2 (○), 0.4 (▼), and 0.8 (△) μM and phenacetin at 20, 40, and 80 μM, respectively.

(a)

(b)