Selective Inhibition of Bakuchicin Isolated from Psoralea corylifolia on CYP1A in Human Liver Microsomes

Figure 5

Lineweaver-Burk plot obtained from a kinetic study of CYP1A-catalyzed phenacetin O-deethylation following 60 min of incubation with bakuchicin at 0, 0.2, 0.4, and 0.8 μM and phenacetin at 20 (●), 40 (○), and 80 (▼) μM in human recombinant cDNA-expressed CYP1A1 (a) and CYP1A2 (b).

(a)

(b)