Effects of Jia-Wei-Xiao-Yao-San on the Peripheral and Lymphatic Pharmacokinetics of Paclitaxel in Rats

Table 1

Matrix effect and recovery of paclitaxel and docetaxel in rat plasma and lymph.

Nominal concentration (ng/mL)	Peak area			Matrix effect (%)	Recovery (%)
	Set 1	Set 2	Set 3
Plasma
Paclitaxel
10	36872 ± 4813	32992 ± 2473	24279 ± 2632	89 ± 7	74 ± 8
100	235603 ± 12101	269808 ± 27215	237379 ± 31147	115 ± 12	88 ± 12
500	1202318 ± 61512	1356123 ± 74986	1265995 ± 133390	113 ± 6	93 ± 10
Average				106 ± 14	85 ± 13
Docetaxel (IS)
250	465608 ± 9230	389823 ± 23305	302862 ± 16985	84 ± 5	78 ± 4
Lymph
Paclitaxel
10	30372 ± 3067	25645 ± 1935	20778 ± 2064	84 ± 6	81 ± 8
100	298923 ± 18866	246724 ± 5850	217499 ± 35420	83 ± 2	88 ± 14
500	2216455 ± 159883	1598223 ± 99812	1341908 ± 180573	72 ± 5	84 ± 11
Average				80 ± 7	84 ± 11
Docetaxel (IS)
250	465609 ± 9330	280022 ± 21317	147762 ± 12713	60 ± 5	53 ± 5

Data expressed as mean ± SD (). Matrix effect is expressed as the ratio of the mean peak area of an analyte spiked after extraction (set 2) to the mean peak area of the same analyte standard (set 1) multiplied by 100. A value of >100% indicates ionization enhancement, and a value of <100% indicates ionization suppression. Recovery was calculated as the ratio of the mean peak area of an analyte spiked before extraction (set 3) to the mean peak area of an analyte spiked after extraction (set 2) multiplied by 100.