Effects of Jia-Wei-Xiao-Yao-San on the Peripheral and Lymphatic Pharmacokinetics of Paclitaxel in Rats

Table 2

Intra- and interday precision (% RSD) and accuracy (% bias) of the UPLC-MS/MS method for determination of paclitaxel in rat plasma and lymph (6 days, 6 replicates per day).

Nominal concentration (ng/mL)	Intraday			Interday
	Observed concentration; (ng/mL)	Precision; (% RSD)	Accuracy; (% bias)	Observed concentration; (ng/mL)	Precision; (% RSD)	Accuracy; (% bias)
Plasma
10	9.58 ± 1.28	13.4	−4.20	9.42 ± 1.36	14.4	−5.77
25	23.9 ± 1.22	5.13	−4.51	24.8 ± 2.11	8.50	−0.88
50	49.5 ± 2.90	5.87	−0.99	48.6 ± 3.25	6.69	−2.88
100	102 ± 7.27	7.10	2.45	99.1 ± 2.46	2.48	−0.89
250	259 ± 9.80	3.78	3.64	257 ± 7.19	2.80	2.76
500	495 ± 4.30	0.87	−1.05	497 ± 4.17	0.84	−0.62
Lymph
10	9.65 ± 1.25	12.9	−3.49	9.21 ± 1.26	13.6	−7.88
25	25.1 ± 2.67	10.6	0.28	25.1 ± 2.34	9.34	0.25
50	52.2 ± 3.04	5.83	4.34	52.4 ± 3.47	6.62	4.70
100	101 ± 4.32	4.30	0.58	101 ± 3.44	3.39	1.42
250	247 ± 10.5	4.26	−1.32	248 ± 14.2	5.71	−0.76
500	502 ± 4.94	0.99	0.33	498 ± 7.66	1.54	−0.37

Data expressed as mean ± SD.