Anti-Inflammatory Effects of Traditional Chinese Medicines against Ischemic Injury in In Vivo Models of Cerebral Ischemia

Table 3

TCMs stabilize blood-brain barrier integrity in the inflammatory cascade in ischemic stroke models.

TCMs	Isolated from the Chinese herb (Chinese name)	Anti-inflammatory actions	Models	References
Methylophiopogonanone A	Mai Men Dong	MMP-9↓, claudin-3↑, claudin-5↑	MCAo; 2 h of ischemia followed by 7 d of reperfusion	[38]
Ligustrazine	Chuan Xiong	MMP-9↓, claudin-5↑, occludin↑	MCAo; 1.5 h of ischemia followed by 22.5 h of reperfusion	[39]
Levo-tetrahydropalmatine	Yan Hu Suo	MMP-2↓, MMP-9↓; claudin-5↑, occludin↑, ZO-1↑	MCAo; 1.5 h of ischemia followed by 24 h of reperfusion	[40]

MMP-9, matrix metalloproteinase-9; ZO-1, zonula occludens-1.