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Evidence-Based Complementary and Alternative Medicine
Volume 2016, Article ID 5769897, 8 pages
http://dx.doi.org/10.1155/2016/5769897
Research Article

Inhibition of Asthma in OVA Sensitized Mice Model by a Traditional Uygur Herb Nepeta bracteata Benth.

1Xinjiang National Clinical Research Base of Traditional Chinese Medicine, Xinjiang Medical University, Urumqi, Xinjiang 830000, China
2College of Basic Medicine, Xinjiang Medical University, Urumqi, Xinjiang 830011, China
3First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang 830011, China

Received 19 November 2015; Revised 12 January 2016; Accepted 17 January 2016

Academic Editor: I-Min Liu

Copyright © 2016 Jing Wang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Asthma is a chronic lung inflammation which affects many people. As current therapies for asthma mainly rely on administration of glucocorticoids and have many side effects, new therapy is needed. In this study, we investigated Nepeta bracteata Benth., a traditional Uygur Herb, for its therapeutics effect in OVA induced asthmatic mice model. Treatment of OVA sensitized asthma mice with extract from Nepeta bracteata Benth. demonstrated improved lung pathology, as well as reduced infiltration of eosinophil and neutrophil. Nepeta bracteata Benth. extract also contributed to the rebalance of Th17/Treg cell via decreasing the Th17 cell and increasing the Treg, which was corresponding with the inhibited Th17 cytokine response and increased IL-10 level. Moreover, the reduced TGF-β level and Smad2/3 protein level also suggested that Nepeta bracteata Benth. extract could inhibit TGF-β mediated airway remodelling as well. Taken together, these data suggested that Nepeta bracteata Benth. may be a novel candidate for future antiasthma drug development.