Research Article
Naoxintong Protects Primary Neurons from Oxygen-Glucose Deprivation/Reoxygenation Induced Injury through PI3K-Akt Signaling Pathway
Figure 7
Effects of LY2940002 on Ca2+ overload, ROS generation, mPTP opening, and caspase-3 activity in OGD/R injured neurons. (a) Effect of LY2940002 on Ca2+ concentration in cytoplasm. (b) Effect of LY2940002 on Ca2+ concentration in mitochondria. (c) Intracellular ROS generation was indicated by DCFDA fluorescence. (d) mPTP opening was detected by calcein fluorescence. (e) Caspase-3 activity. Data are expressed as mean + SD. per group. , compared with control. , , compared with OGD/R. , , compared with OGD/R + BNC.
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