Uliginosin B, a Possible New Analgesic Drug, Acts by Modulating the Adenosinergic System

Figure 2

Effect of pretreatment with DPCPX (0.1 mg/kg, i.p. (a)) or ZM 241385 (ZM: 3 mg/kg, i.p. (b)) 15 min before the treatment with uliginosin B (ULI: 15 mg/kg, i.p.) in the hot-plate test. Percentages of maximal possible analgesic effect (% MPE) are presented as means ± SEM ( mice/group). compared to vehicle group; compared to uliginosin B (15 mg/kg, i.p.) group (ANOVA followed by Student-Newman-Keuls). Data are presented in mean ± SEM ( mice/group). Significantly different values were detected by one-way ANOVA followed by Student-Newman-Keuls: compared to vehicle.

(a)

(b)