The Rhizome Mixture of Anemarrhena asphodeloides and Coptis chinensis Attenuates Mesalazine-Resistant Colitis in Mice

Figure 1

Effect of DWac on the gut microbiota composition in mice with TNBS-induced colitis. (a) Effect on phylum level. (b) The ratio of Firmicutes to Bacteroidetes (). (c) The ratio of Proteobacteria to Bacteroidetes (). (d) Effect on family level. Genomic DNA was extracted from the fecal samples taken from mice treated with vehicle alone (N1~N5), TNBS alone (T1~T5), or DWac (20 mg/kg) in the presence of TNBS (DW1~DW5) and analyzed by pyrosequencing of the bacterial 16S rRNA fragments (). (e) Principal coordinate analysis (PCoA) plot. The plot shows the clustering pattern among mice treated with vehicle alone (N1~N5), TNBS alone (T1~T5), or DWac in the presence of TNBS (DW1~DW5) based on weighted pairwise Fast UniFrac analysis. versus N (normal) group. versus T (TNBS) group.

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